Topic: voluntary wheel running

Estrogens regulate a variety of processes in the central nervous system (CNS), including inflammatory responses. Therefore, postmenopause, a hypoestrogenic state, may contribute to an increased risk of developing neuroinflammatory-related disorders. Thus, it is proposed to introduce lifestyle changes that could have beneficial effects on the CNS. Regular, moderate physical activity is being considered as a potential intervention for preventing disruption of the neuroinflammation process. The aim was to investigate the impact of voluntary wheel running on neuroinflammation, including Nlrp3 infl

Neuropathic pain is an intractable disease which in case opioids provide inadequate analgesia. It has been previously reported that voluntary wheel running prevented persistent hyperalgesia in sciatic nerve ligation (PSNL) mice. However, the mechanism of the preventive effect of the voluntary wheel running on persistent hyperalgesia was unknown. Since the anterior cingulate cortex (ACC) has been known to play an important role in chronic pain, we investigated factors associated with the attenuated hypersensitivity on voluntary wheel running in the ACC of the PSNL mice.A partial sciatic nerve l

In rodent models with intracranial tumor formation, severity assessment and humane endpoint determination are fundamental for ethical and legal reasons. We here evaluated whether voluntary wheel running (VWR) would enable classification of severity after surgery for subcutaneous transmitter-implantation, intracranial tumor-cell-injection and resection, as well as humane endpoint detection. VWR behavior was compared to body weight, clinical state, together with heart rate (HR) and activity (Act) generated via transmitter. Male BDIX rats (n=14) were single-housed in cages equipped with a running

Despite an overall increase in caloric needs, regular physical activity has been associated with improved appetite signaling. The neurobiological mechanisms underlying this sensitization remain unclear. We employed a voluntary wheel running protocol to investigate how physical activity affects gut-brain communication of vagal sensory neurons for the control of feeding behavior in mice. We find that physically active mice exhibit a significant decrease in food intake in response to the delivery of nutrients directly into the stomach, as compared to sedentary controls. Further, sensitivity to ch