Topic: VPA

Introduction: The rational polytherapy of epilepsy during pregnancy is challenging. VPA represents an old antiepileptic with broad spectrum indications and LEV is relatively new antiepileptic used for the treatment of generalized tonic-clonic and juvenile myoclonic epilepsy and adjunctive therapy for focal seizures. Combination of these two antiepileptics during pregnancy, according to the cohort study (Gašparović at al., 2020), was the most common. Aim: The aim of the present study was to assesse the behavioral performance of the mice whose mothers were treated with combination of VPA and LEV

Autism spectrum disorder impacts various aspects of the behavioral phenotype. Even in highly functioning autistic patients, the domains most affected include social behavior, behavioral flexibility, and linguistic development. While the first two are relatively easy to model in laboratory rodents, vocal learning is not within their behavioral repertoire. Conversely, songbirds, such as the zebra finch (Taenopygia guttata), develop their vocal communication (song) through social learning, making them a potentially valuable model for human speech development. Zebra finches, highly social colonial