Topic: Western blotting

Transcranial focused ultrasound (tFUS) targets deep brain areas by non-invasively administering low intensity ultrasound through the brain with a high spatial resolution (Zhang et al., 2021). Previous results indicate that stimulating neural cells at specific pulsing frequencies is neuroprotective (Manippa et al., 2022). We were therefore interested in determining whether a similar approach could be taken with focused ultrasound stimulation. To this end, we prepared acute rat hippocampal slices and exposed them to 40Hz pulsing ultrasound for 1hr. Following a proteomics screen, we noted an incr

Ischemic stroke is one of the most serious and widespread neurological emergencies in the world. It is characterized by rapid disruption of brain blood flow, and it can cause irreversible damage to brain cells leading to permanent disability or death. Currently, treatment options are limited and fail to completely prevent or reverse brain damage. It is therefore essential to pursue innovative approaches to improve the prognosis and quality of life of ischemic stroke patients.Brain organoids are three-dimensional models that can reproduce the cellular composition, structure, and neuronal connec