ePoster · Computational Neuroscience
In-vivo dynamical effects of structural white matter disconnections
Riccardo Leone, Steven Geysen, Gustavo Deco, Xenia Kobeleva · Bernstein Conference 2024
White matter (WM) tracts shape the brain’s dynamical activity, and their damage (e.g., disconnections) results in functional alterations and cognitive symptoms [1]. Here, we use neural mass modeling to test the in-vivo effects of WM disconnections [2]. We create models of local versus global, and edge versus nodal effects of WM disconnections in a large fMRI dataset comprising individuals affected by varying degrees of white matter hyperintensities (WMH), in order to estimate the impact of WMH on brain dynamics in a data-driven manner. We use a virtual-lesioning (disconnectome [3]) approach in