Topic: WiChR

Aims: Temporal lobe epilepsy is a neurological disorder characterised by the occurrence of spontaneous seizures. Current treatment methods consist of anti-epileptic drugs, resective surgery or neuromodulation each with significant risks and/or side-effects. Responsive neuromodulation could provide a solution by providing spatial and temporal specificity. In this study, we evaluated whether seizures could be detected with a self-designed embedded system and terminated through activation of the WiChR opsin in the intrahippocampal kainic acid mouse model of temporal lobe epilepsy.Methods: Mice we

The spatio-temporal precision of Optogenetics is one of the main reasons for its versatile utilization within Neurosciences. Recently developed tools like BiPOLES allow bidirectional optogenetic control regarding activation and inhibition. But while the current mode of inhibition, using anion-selective channelrhodopsins proved effective when targeted to the soma of the neuron, it is yet insufficient in terminals and smaller compartments. Building upon the recent discovery of light gated potassium channels, K-BIPOLES could constitute a promising alternative with the light controlled outflow of