Topic: wireless optogenetics

Associative recognition memory, such as finding your car in a carpark, requires the quick integration of familiarity, spatial location and temporal information that is vital for episodic experience. The medial prefrontal cortex (mPFC) is a key integration hub within the associative recognition memory circuit as it receives long range excitatory inputs from the nucleus reuniens (NRe) and intermediate hippocampus (iCA1), both pathways being critical for learning. Inhibitory interneurons play essential roles in spatial and working memory function by gating signal flow and sculpting microcircuit d

Many neuroscience studies in rodents are limited spatially and temporally by the use of tethered devices, head-fixed recordings or battery-powered telemetric implants. When subtle behavioural readouts are needed, protruding implants may affect neurophysiological and psychobehavioural parameters. We have successfully deployed and continue to develop ADInstruments’ KAHA Wireless Optogenetics Biopotential Telemeter which allows simultaneous user-defined optogenetic stimulation (460nm) and continuous electroencephalogram recording at 2kHz. Powered by inductive charging to remove the limitations of