Topic: Wisconsin Card Sorting Test

Animals can switch rapidly between multiple well-learned tasks without being explicitly instructed on which task to perform, a cognitive function termed un-cued task switching. This function relies on higher-order cortical areas to maintain and update the task rule representation, and use this representation to gate the sensorimotor pathway. How different brain regions and neuronal types interact to achieve this function is not well understood. We investigated a collection of modular recurrent neural networks (RNNs) trained to perform an analog of the Wisconsin Card Sorting Test (WCST), a clas

Lesion studies have elucidated the distinct roles played by different areas in the prefrontal cortex (PFC) in guiding behaviour according to abstract rules, as observed in a macaque-adapted version of the Wisconsin Card Sorting Test (WCST). Nevertheless, we do not fully understand how these functional specialisations relate to the underlying neuronal activity across these different prefrontal regions. In this study, we present novel insights derived from our multi-area multi-electrode recording in non-human primates (NHPs). We chronically implanted Utah arrays in dorsolateral PFC, ventrolatera