Topic: Y-maze

Pain is a complex sensory and emotion experience that typically facilitates a learning event so that an individual may avoid future harm. However, in a chronic pain context, pain that is experienced at inappropriate times no longer provides a useful function and may impair learning. Cognitive deficits including difficulties with learning and memory recall have been well documented in the clinic but pre-clinical data is lacking and the neural basis remains poorly understood. Using a chronic constriction injury (CCI) model of neuropathic pain in mice, combined with ex vivo electrophysiology and

Neurogenesis is the process where neural stem cells (NSCs) develop into functional neurons. It comprises proliferation, differentiation, migration, axonal and dendritic targeting, and synaptic integration. Meropenem is a broad-spectrum carbapenem that treats various infections. It can penetrate most body fluids and tissues, cross the blood–brain barrier, and obtain a concentration within the cerebrospinal fluid close to that of blood plasma. However, no research has established a link between meropenem and neurotoxic effects on the brain and the subsequent behavioral activity. This project aim

Inflammatory bowel disease (IBD) is associated with inflammatory activity in the GI tract and birth complications in pregnant women. The long-term impact of gestational IBD on offspring development, however, has not been examined. Here, we employed dextran sulfate sodium (DSS, 2.5% in drinking water on GD9-12) to induce colonic mucosa ulceration to the pregnant C57BL/6 mice dams. Offspring from DSS-treated dams were compared with non-treated dams at juvenile (PND 30) and adult age (PND 70) in behavioural tests sensitive to the acute gestational infection induced by polyinosinic:polycytidylic a

Neurogenesis is primarily defined as the development of neurons, which occurs in several locations of the brain including the dentate gyrus of the hippocampus. The proliferation stage of neurogenesis is the earliest stage in which the neural stem cells (NSCs) produced can be affected by a variety of factors, such as antibiotic toxicity. Fosfomycin (FOS) is a very reactive broad-spectrum antibiotic and is commonly prescribed for urinary tract infections (UTI). Previous data from our lab indicated a serious negative effect on NSCs when FOS was administered to rats. In this study, we aim to inves

Numerous reports have correlated lysine deficiency with cognitive decline; however, the effect of lysine deficiency on hippocampal neurogenesis has not yet been addressed in the literature. This study hypothesizes the impairment of hippocampal neurogenesis and thus hippocampal-related functions due to mild and severe induced dietary lysine deficiency. Here, we aim to observe the effect of mild and severe lysine deficiency on rodents' cognitive functions, memory, and adult hippocampal neurogenesis. In this project, male adult Sprague-Dawley rats were divided into three randomized groups (8 rats