Zebrafish larvae

…of spontaneous activity in multiple zebrafish larvae. This shared latent space, composed of spatially loc

…study the role of internal states in zebrafish larvae behavior, leveraging a rich dataset of three million movements recorded during spontaneous behavior, photomotor responses, optomotor responses, and visually driven escape in the zebraf

…whole-brain calcium imaging in zebrafish larvae to investigate the structural and genetic basis of functional connectivity (FC) at single-cell resolution. Neural activity from $\sim$50,000 neurons was recorded in head-restrained transgenic larvae expressing a pan-neuronal calcium sensor, while monitoring their tail movem

…With Zebrafish larvae, we can perform whole-brain single-neuron imaging, yet current cross-individual comparison methods are limited to sensory-driven paradigms. Thus, analyzing spontaneous brain activity across zebrafish larvae remains challenging. Presenting a novel approach, we employ a single Restricted Boltzmann M

Cerebrospinal fluid (CSF) is a clear, colorless fluid that bathes the central nervous system and is essential for brain homeostasis. CSF flows through interconnected ventricles which are lined by ependymal cells that generate a directional flow upon beating of their motile cilia. Defects in motile cilia can lead to a variety of neurological conditions like hydrocephalus, which is characterized by an accumulation of CSF in the brain. Nevertheless, the function of motile cilia-mediated fluid flow and its impact on brain development and physiology is still poorly understood. To address these ques

…GRD aetiology might be addressed using zebrafish larvae model. In this study

…stimulation in head-restrained zebrafish larvae to study whole-brain circuits. In this study, we present significant enhancements to such a setup to enable precise rotational movements along arbitrary axes between rol

The interplay between spontaneous and sensory-driven activity plays a critical role in regulating neuronal structure and function of neuronal circuits during development. Here, we investigated how deprivation of visual inputs (dark rearing) during the early stage of development affects sensori-motor integration at the behavior and neuronal circuit level. Due to the intrinsic characteristic of the mammalian brain, it has not been possible to analyze simultaneously the impact of neuronal activity in shaping circuits across neuronal populations in distinct brain areas. To overcome this limitation

…this, we address these questions in zebrafish larvae, leveraging their simpler and conserved DRN.Here, we establish a

Interoception it has a large influence on how animals make decisions and is necessary to adjust internal body function to the organism’s needs, such as during rest or hunting. The heart is essential in the process to adapt the animal to changing circumstances by increasing or decreasing its rate. Heart rate modulation occurs through the communication between sensory and motor ganglia of the autonomic nervous system. The vagal neurons transmit information to the heart and send information via the autonomic nervous system to the central nervous system. How they interact to change heart activity,

…the regulation of neuronal activity in zebrafish larvae by three-photon excitation of a photoswitchable muscarinic agonist at 50

…calcium imaging of triple transgenic zebrafish larvae optic tectum (OT), letting us simultaneously record spontaneous activity of 1000s of neurons in the absence of stimulation. What is the composition of cell types within the assemblies? What role do the inhibitory and excitatory neurons play

…turning region (ARTR) of zebrafish larvae using calcium-imaging recordings of the spontaneous activity of hundreds of neurons. While our data-driven model is trained to solely reproduce the short-term statistics of the neural activity, its dynamics exhibits persistence on much longer time scales. The model's persistence time decreases with water temperature in agreement with neurona

…we have used PiVR to present fruit fly larvae with virtual olfactory realities, adult fruit flies with a virtual gustatory reality and zebrafish larvae with a virtual light gradient. PiVR operates at high temporal resolution (70Hz) with low latencies (<30 milliseconds) while being affordable (<US$500) and easy