Topic: ZO-1

The neurovascular unit (NVU) represents the structural and functional relationship between the neural tissue and the blood. Neurovascular dysfunction has been highlighted in neuropsychiatric afflictions, but it is still unclear whether it is a cause or a consequence of the pathology. Studying how NVU components associate might clarify its role on the emergence of emotional-cognitive dysfunction. This study aims at investigating whether the development of depressive-related loss of motivation is grounded on NVU modifications impacting the permeability of the blood-brain barrier (BBB) and in par

Astronauts endure repetitive episodes of hypergravity (HG) during takeoff and landing of spaceflights, and also in space due to microgravity. We have recently shown subtle BBB breakdown in a mouse model of centrifugation-induced HG (Dubayle et al., 2023); here we have evaluated if the blood-spinal cord barrier (BSCB) was also damaged in this model.Eight-week-old C57Bl/6J male mice were subjected to HG in a centrifuge at 2g for 24h, while control mice stayed in normogravity (N=9/group). Mice were sacrificed after centrifugation, and thoracic spinal cords collected for immunohistochemistry. For

Diabetes mellitus is characterized by hyperglycemia due to lack of insulin production or function. Chronic hyperglycemia leads to damage microvascular dysfunction, including in hippocampus. Previous studies found that diabetes can cause blood-brain barrier (BBB) dysfunction and implicate cognitive decline in the hippocampus. BBB comprises endothelial cells attached with tight junctions to protect pathogens in circulation through the brain parenchyma. Interestingly, melatonin, a neurohormone secreted from pineal gland, is a neuroprotective effect and plays a vital role in learning and memory. T