Biomechanics seminars

Cryopreservation constrains manufacturing and clinical delivery of immune cells such as NK and T cells. DMSO protects against freezing but becomes toxic at physiological temperatures; associated infusion morbidity can require washing or divided dosing that diminishes therapeutic effectiveness. This talk presents an alternative in which reversible, cytocompatible hydrogels encapsulate cells before freezing without DMSO. The speaker examines evidence that encapsulation cushions osmotic stress, suppresses kinetic and phase transitions, and reduces injury caused by extracellular ice growth and fusion. The discussion covers recovery efficiency, function after thawing, control of biological stress responses, and the challenges of extending the approach to clinical-scale cell preservation.

UCL Department of Neuroinflammation Seminar by Professor Emad Moeendarbary (Professor of Cell Mechanics and Mechanobiology, UCL Mechanical Engineering) on how biophysical factors such as substrate stiffness and axon geometry regulate oligodendrocyte behavior and myelin formation, presenting the AxoMetic in vitro myelination platform for discovery of remyelinating therapies.

Suhrid Ghosh will present work on how cell mechanics and cytoskeletal dynamics shape the evolution of reproductive structures in Drosophila ovaries. Cross-species morphology, ex-vivo live imaging, perturbations of cortical tension, and newly isolated terminal-filament cells reveal how somatic-cell deformability can alter ovariole architecture and reproductive fitness.

Join Us for the Memory Decoding Journal Club! A collaboration of the Carboncopies Foundation and BPF Aspirational Neuroscience. This time, we’re diving into a groundbreaking paper: "Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons