Chemical Biology podcasts

Mariana Kneppers, Neil Withers and Phillip Broadwith discuss molecular glues and efforts to target cancer-related proteins previously considered difficult to drug. They also explore how analysis of fibres and dyes helps researchers investigate and conserve the Bayeux Tapestry.

Hosted by Mariana Kneppers

Carolyn Bertozzi explains why sugars on cell surfaces matter for communication between cells and how new chemical methods make these complex molecules accessible to research. The discussion connects this work to neuroscience, biological aging and drug development.

Hosted by Nicholas Weiler

The concluding episode of Unexplainable’s Life from Scratch series asks how researchers should judge risks when attempting to redesign living systems. Kate Adamala, David Relman and John Glass discuss synthetic biology and concerns about mirror life, whose molecular handedness would differ from that of existing organisms. The conversation considers the limits of anticipating biological consequences, the responsibilities of researchers and reasons to pause particular lines of work.

Mariana Kneppers, Mason Wakley and Frances Briggs reflect on 25 years of click chemistry and its spread into medicine and materials research. A second discussion examines covalent bonding in actinide elements and the experimental challenges of understanding how the heaviest atoms share electrons.

Hosted by Mariana Kneppers

Tanja Janko interviews chemist Lee Cronin about Assembly Theory, chemical complexity, and the emergence of life. They discuss how molecules can reflect the history of their assembly, whether homochirality could be an early form of chemical selection, and how the Chemputer could make chemistry programmable. Other topics include the distinction between patterns and codes in biology, complex molecules as possible evidence of life on Mars, and primitive cell-like behaviour in inorganic polyoxometalate systems.

Hosted by Tanja Janko