From Our Neurons to Yours

Neurobiologist Tom Clandinin joins Nicholas Weiler to explore how interacting genetic, cellular and metabolic systems maintain brain health over a lifetime, and how their breakdown contributes to neurodegeneration. The discussion moves beyond single explanations such as inflammation or waste clearance to a systems-level study of brain resilience. Clandinin describes a collaborative programme combining large-scale genetic perturbations in flies and mice with molecular, circuit and behavioural measurements. Computational models will connect these observations across cell types, predict interactions and guide experiments toward potential ways to strengthen the aging brain’s maintenance systems.

Hosted by Nicholas Weiler

Carolyn Bertozzi explains why sugars on cell surfaces matter for communication between cells and how new chemical methods make these complex molecules accessible to research. The discussion connects this work to neuroscience, biological aging and drug development.

Hosted by Nicholas Weiler

Jonathan Long discusses the expanding scientific study of peptides, from improved methods for discovering molecules in the body to the success of GLP-1 medicines. The conversation distinguishes research progress from untested wellness claims and examines the search for compounds that reproduce aspects of exercise biology.

Hosted by Nicholas Weiler

Corey Keller discusses how transcranial magnetic stimulation can probe and influence brain networks. He explains efforts to measure the brain's response to stimulation and to understand why treatment outcomes differ, outlining the opportunities and remaining uncertainties in developing more precise psychiatric interventions.

Hosted by Nicholas Weiler

Leanne Williams explores how brain imaging could help explain biological differences among people with similar mental-health symptoms. She describes research on brain-network patterns in depression and the possibility of using those measurements to support more individualized diagnosis and treatment.

Hosted by Nicholas Weiler

Julia Kaltschmidt investigates whether signaling between the gut and brain helps explain persistent fatigue. She describes research on the enteric nervous system and sickness responses, including a proposed reflex that could connect infection to longer-lasting symptoms and guide future work on biomarkers.

Hosted by Nicholas Weiler

Monther Abu-Remaileh examines the cell's recycling machinery and its possible role in neurodegeneration. He explains how lysosomes process cellular material, why failures in that system can affect neurons, and how studying this biology may reveal connections among protein accumulation, aging and brain disease.

Hosted by Nicholas Weiler

Cory Shain discusses efforts to map language processing in individual brains with greater precision. Combining measurements from different recording methods, the research aims to explain how people understand and produce language and to inform future technologies for restoring communication.

Hosted by Nicholas Weiler

Nicholas Weiler talks with Guosong Hong about overcoming the limited penetration of light into brain tissue. Inspired by transparent tissues in glass frogs and the eye, Hong describes approaches involving fluorescent nanomaterials, focused ultrasound and molecules that temporarily reduce optical scattering. The conversation examines experiments with a common food dye and a project to genetically engineer mice with transparent brains from birth. These techniques could provide new ways to observe neural circuits and study how the brain develops and functions.

Hosted by Nicholas Weiler

Nicholas Weiler and neurologist Katrin Andreasson discuss connections between inflammation, energy metabolism and Alzheimer's disease. Andreasson describes how aging can alter microglia and astrocytes, affecting the immune and metabolic support that neurons receive. The conversation explores research on inflammatory signaling and the possibility that immune dysfunction outside the brain contributes to neurodegeneration. It also examines experiments in which targeting peripheral inflammation restored memory in mouse models, and why human clinical studies are needed to establish whether these findings can lead to effective treatments.

Hosted by Nicholas Weiler