What an immune invasion teaches us about Alzheimer’s disease

Nicholas Weiler interviews pathologist and computer scientist Julia Belk about evidence that blood-derived immune cells gradually replace resident microglia in ageing human brains. They discuss how somatic mutations can reveal the origins of these cells, the relationship between clonal hematopoiesis and Alzheimer’s risk, and why findings in humans may differ from common mouse models. The conversation explores possible research directions for brain immunotherapy without treating them as established treatments.