Mouse models

…Research will use mouse models, neurophysiology, biology and immunology to investigate how social behaviour and neural circuits affect responses to pathogen infection. The programme aims to understand brain–body and neuroimmune regulation of physiological functions and whether neural activity can modulate immune responses. The appointment is based at the Wako campus; employment is planned from 1 April 202

…human in vitro systems and mouse models support comparisons across developmental stage, brain region and sex. Experience in molecular and cellular research is required; iPSC-derived models, microglia–neuron cocultures, flow cytometry, imaging, animal models or bioinformatics are advantage

…using organoid transplantation, mouse models, CRISPR, single-cell sequencing, flow cytometry and spatial methods. It seeks evidence for rational combination therapies and begins in October 2027.

An intriguing, relatively unexplored therapeutic avenue to investigate epilepsy is the interaction of sleep mechanisms and seizures. Multiple lines of clinical observations suggest a strong, bi-directional relationship between epilepsy and sleep. Epilepsy and sleep disorders are common comorbidities. Seizures occur more commonly in sleep in many types of epilepsy, and in turn, seizures can cause disrupted sleep. Sudden unexplained death in epilepsy (SUDEP) is strongly associated with sleep. The biological mechanisms underlying this relationship between seizures and sleep are poorly understood,

…Genetic mouse

…have been reported in different animal models of stress-induced depressive-like behaviors. In fact, most of our knowledge of the biological basis of MDD is derived from studies of chronic