Migraine: a disorder of excitatory-inhibitory balance in multiple brain networks? Insights from genetic mouse models of the disease
Thursday, October 28, 2021
16:00 UTC
Prof Daniela Pietrobon
Department of Biomedical Sciences and Padova Neuroscience Center, University of Padova, Italy
Recording
Open recording
Hosted by The Brain Prize Series70 minutes
Abstract
Migraine is much more than an episodic headache. It is a complex brain disorder, characterized by a global dysfunction in multisensory information processing and integration. In a third of patients, the headache is preceded by transient sensory disturbances (aura), whose neurophysiological correlate is cortical spreading depression (CSD). The molecular, cellular and circuit mechanisms of the primary brain dysfunctions that underlie migraine onset, susceptibility to CSD and altered sensory processing remain largely unknown and are major open issues in the neurobiology of migraine. Genetic mouse models of a rare monogenic form of migraine with aura provide a unique experimental system to tackle these key unanswered questions. I will describe the functional alterations we have uncovered in the cerebral cortex of genetic mouse models and discuss the insights into the cellular and circuit mechanisms of migraine obtained from these findings.
Topics
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