Cortical spreading depression

Cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms. The mechanisms of initiation of CSD in migraineurs are unknown. Insights into these mechanisms can be obtained by studying the mechanisms of facilitation of CSD initiation in genetic mouse models of the disease. Here, we investigated these mechanisms in knock-in mice carrying a mutation in cacna1a causing familial hemiplegic migraine (FHM1 mice). High KCl puffs of increasing duration up to the threshold duration eliciting a CSD were applied on layer 2/3 of cerebra

…migraine pathogenesis via regulating cortical spreading depression, neuroinflammation, hyperalgesia and trigeminovascular system activation and sensitization. However, whether TRPA1 could affect photophobia, a symptom that affects ~80% migraineurs, is unknown. In this study, we examined whether TRPA1 activation triggers photophobia, and displays a gender-specific difference in photophobia behavior. C57BL/6J mice were used to assess mouse behavior in both dark and light compartments of a chamber. The photophobia behavior was

…whose neurophysiological correlate is cortical spreading depression (CSD). The molecular, cellular and circuit mechanisms of the primary brain dysfunctions that underlie migraine onset, susceptibility to CSD and altered sensory processing remain largely unknown and are major open issues in the neurobiology of migraine. Genetic mouse

…supporting the importance of TVS, cortical spreading depression and parameningeal inflammation will be explored as will the implications of newly discovered microvascular channels within the meninges on an attack.

…results showed changes compatible with cortical spreading depression in migraine without aura effectively negating the then prevailing vasospastic/ischemic theory. In migraine without aura no changes in brain blood flow. This difference was crucial for the separation of migraine with aura and migraine without aura in the first and subsequent editions of the international headache classification headed by me. Then a human migraine provocation model th