Immune cells

Scott J. Russo presents cross-species research on how immune cells outside the brain influence neural circuits implicated in anxiety and depression. The session examines stress-related disruption of neuroimmune communication, including inflammation and increased monocyte abundance. It connects these mechanisms with translational efforts to develop targeted interventions for major depression and post-traumatic stress disorder.

…Activity and differentiation of immune cells i

Phenotypic and compositional changes of immune cells in cerebrospinal fluid (CSF) can be used as biomarkers to help diagnose and track disease activity for neuroinflammatory and neurodegenerative diseases, such as multiple sclerosis (MS) and Alzheimer´s disease (AD). The CSF is the compartment in closest proximity to the central nervous system (CNS) with unique immune cell composition and routine CSF collection is integral for diagnosing various CNS disorders, offering a more practical alternative to assess the CNS. In this study, we described an end-to-end workflow to perform in-depth single-

Neurostimulation employing photoactive organic semiconductors presents a promising alternative to conventional techniques, enabling targeted action and wireless control through light. This study investigates the efficacy of stimulation of the neuronal networks in vivo using organic electrolytic photocapacitors (OEPC) and explores the interactions between the device and neural tissue following a long-term implantation.OEPC implants were positioned subdurally on the somatosensory cortex of adult rats, with the craniectomy site sealed by a transparent window. Three weeks post-implantation, animal

…their contribution to brain autoimmune disease is still unknown. We aimed to assess the role of meningeal neural progenitor

Membrane interfaces formed at junctions between cells are often associated with characteristic patterns of membrane protein organization, such as in epithelial tissues and between cells of the immune system. While this organization can be influenced by receptor clustering, lipid domain formation, and cytoskeletal dynamics, this talk will describe how cell surface molecular height can directly contribute to the spatial arrangement of membrane proteins and downstream signaling. Using a new optical method for characterizing molecular height, together with experiments using giant vesicles in vitro

The Chiu laboratory focuses on neuro-immune interactions in pain, itch, and tissue inflammation. Dr. Chiu’s research has uncovered molecular interactions between the nervous system, the immune system and microbes that modulates host defense. He has found that sensory neurons can directly detect bacterial pathogens and their toxins to produce pain. Neurons in turn release neuropeptides that modulate immune cells in host defense. These interactions occur at major tissue barriers in the body including the gut, skin and lungs. In this talk, he will discuss these major neuro-immune interactions and

…(including IL-2, IFN-g, TNF, IL-6) of immune cells in vitro, with unprecedented resolution. To understand the complex emerging dynamics, we use interpretable machine learning techniques to build a generative model of cytokine response. We discover that, surprisingly, immune activity is encoded into one global parameter, encoding ligand antigenic properties and to a less extent ligand quantity. Based on this we build a simple interpretable model which can fully explain the broad variability of cytokines dynamics. We