Bridging the Translational Gap in Pancreatic Cancer Through Biology-First Modeling

Examine how interpretable transcriptomic models and three-dimensional pancreatic cancer systems can connect patient biology with laboratory experiments. Adding fibroblasts and immune cells changes epithelial, inflammatory and signalling programmes in bioprinted models, revealing therapeutic biology absent from monocultures. The presentation uses these examples to consider experimental complexity, biological state and translational relevance.