Clinical Pharmacology seminars
November 2022
How can we treat visceral pain?
David Bulmer· Department of Pharmacology, University of Cambridge
Recorded
Chronic pain is a leading cause of morbidity, common to patients with gastrointestinal diseases such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Most pain killers are largely ineffective against this type of pain or restricted for use in these patients due to gut related complications and risk of addition. A significant unmet clinical need therefore exists to develop novel non-opioid based visceral analgesics.
March 2022
Antisense oligonucleotide mediated exon skipping therapy development for Duchenne muscular dystrophy takes more than an oligonucleotide
Annemieke Aartsma-Rus· Leiden University Medical Center, the Netherlands
Recorded
May 2021
New Frontiers in Understanding and Treating Migraine Headaches
Lars Edvinsson· Lund University, Sweden & University of Copenhagen, Denmark
Recorded
In this presentation I will describe how the CGRP project started and culminated in the development of gepants and mAbs for successful therapy. The outstanding question regarding the preponderance of female migraineurs also remains. I will present views on the reason behind this and suggest that understanding the hormonal influence will pave the way to alleviating hormone related migraine.
April 2021
Pharmacokinetics trumps pharmacodynamics during drug reward valuation
Serge Ahmed· CNRS Université de Bordeaux
Recorded
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