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BACTERIOPHAGES DETECTING AMYLOID BETA OLIGOMERS HAVE DIAGNOSTIC AND THERAPEUTIC POTENTIAL IN ALZHEIMER’S DISEASE
Lucas Lumeijand 7 co-authors
University of Amsterdam
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-194
Presentation
Date TBA
Board: PS07-10AM-194
Event Information
Poster Board
PS07-10AM-194
Poster
View posterAbstract
Amyloid beta (Aβ) peptides, specifically when aggregated into soluble oligomers, play a large role in Alzheimer's disease (AD) pathogenesis. However, proficient methods to detect these Aβ oligomers in brain tissue are lacking. We developed synthetic M13 bacteriophages (phages) displaying Aβ-derived peptides on their surface that selectively interact with Aβ oligomers. We used two different peptides, AB30-39 and AB33-42, of which the former inhibits and the latter promotes Aβ aggregation. We have shown that these phages detect Aβ oligomers in post-mortem hippocampal tissue from AD (APP/PS1) mice at an early age, before Aβ plaque formation is observed. Our recent findings show that ex vivo detection of Aβ oligomers is possible after peripheral administration of the phages in APP/PS1 mice, indicating that the phages can cross the blood-brain barrier and that they have potential for the diagnosis of Aβ oligomers in vivo. Ongoing experiments are aimed at finding possible therapeutic effects of AB30-39-displaying phages on Aβ-induced synaptic and memory deficits. Altogether, phages that display Aβ-derived peptides are a promising tool in diagnosing AD at the early stage of pathogenesis, with potentially therapeutic benefits.
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