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A COMPARATIVE STUDY ON THE EFFECTS OF "ANTI-PD GRANULES" AND PROBIOTICS ON THE INTESTINAL FLORA OF PARKINSON'S DISEASE MODEL MICE
Xiaohui Zhaoand 1 co-author
Shanghai Pudong New Area People's Hospital
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-296
Presentation
Date TBA
Board: PS05-09AM-296
Event Information
Poster Board
PS05-09AM-296
Poster
View posterAbstract
Aim: Compare effects of "Anti-PD Granules" and probiotics on gut microbiota in Parkinson’s disease (PD) mice.
Method: 100 C57BL/6 mice were divided into: blank (A), PD model (B), PD+probiotics (C1), PD+"Anti-PD Granules" (C2), and PD+combined (C3). PD was induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) injection. Fecal samples were collected pre- and post-intervention. Gut microbiota DNA was sequenced and analyzed bioinformatically.
Results: Number of Operational Taxonomic Units (OTUs) decreased in B (p<0.01) but unique OTUs increased in C1–C3 (p<0.01).
Alpha diversity (Simpson index) was higher in C1–C3 than B (p<0.01). PCoA showed C1–C3 clustered closer to A after intervention, while B was distinct. C1 significantly increased Actinomycetes and Akkermansiaceae while reducing Bacteroides vs. B (p<0.01).
Conclusion: Both interventions improved microbiota diversity and structure in PD mice. Probiotics showed superior modulation of species composition, with no synergistic effect from combined treatment.
Method: 100 C57BL/6 mice were divided into: blank (A), PD model (B), PD+probiotics (C1), PD+"Anti-PD Granules" (C2), and PD+combined (C3). PD was induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) injection. Fecal samples were collected pre- and post-intervention. Gut microbiota DNA was sequenced and analyzed bioinformatically.
Results: Number of Operational Taxonomic Units (OTUs) decreased in B (p<0.01) but unique OTUs increased in C1–C3 (p<0.01).
Alpha diversity (Simpson index) was higher in C1–C3 than B (p<0.01). PCoA showed C1–C3 clustered closer to A after intervention, while B was distinct. C1 significantly increased Actinomycetes and Akkermansiaceae while reducing Bacteroides vs. B (p<0.01).
Conclusion: Both interventions improved microbiota diversity and structure in PD mice. Probiotics showed superior modulation of species composition, with no synergistic effect from combined treatment.
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