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LAYER-1 NDNF+ INTERNEURONS MEDIATE THE INTEGRATION OF SLEEP OSCILLATIONS CRITICAL FOR MEMORY CONSOLIDATION
Aurélie Brécierand 1 co-author
INSERM
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-673
Presentation
Date TBA
Board: PS07-10AM-673
Event Information
Poster Board
PS07-10AM-673
Poster
View posterAbstract
Temporal coordination of hippocampal sharp-wave ripples and slow oscillations supports information transfer during NREM sleep. Recent evidence suggests L1 NDNF+ neurons initiate down-states and generate slow oscillations. We hypothesize that these inhibitory neurons are key neocortical elements that promote ripple integration. We combined miniscope Ca2+ imaging with LFP recordings from CA1 and neocortical areas to monitor L1 NDNF+ neuron activity in naturally sleeping, freely moving mice. At the population level, our results revealed that L1 NDNF+ neuron activity is, on average, lower during NREM, as is the activity of pyramidal neurons. However, more precise analysis uncovered a subpopulation of L1 NDNF+ neurons specifically active during NREM, suggesting that a part of these interneurons might play an important role in inhibiting the activity of excitatory cells during NREM sleep. NREM-active L1 NDNF+ neurons' activity was dependent on the temporal coupling of hippocampal sharp-wave ripples with other critical oscillations, deciphering a potential contribution of these neurons to memory consolidation.
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