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A TIME WINDOW FOR MEMORY CONSOLIDATION DURING NREM SLEEP REVEALED BY CAMP OSCILLATION
Ziru Dengand 3 co-authors
Shanghai Jiao Tong University School of Medicine
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-607
Presentation
Date TBA
Board: PS03-08AM-607
Event Information
Poster Board
PS03-08AM-607
Poster
View posterAbstract
Memory formation requires specific neural activity in coordination with intracellular signaling mediated by second messengers such as cyclic adenosine monophosphate (cAMP). However, the real-time dynamics of cAMP remain largely unknown. Here, using a genetically encoded cAMP sensor with high temporal resolution, we found neural-activity-dependent rapid cAMP elevation during learning. Interestingly, in slow-wave sleep, during which memory consolidation occurs, the cAMP level in mice was anti-correlated with neural activity and exhibited norepinephrine b1 receptor-dependent infra-slow oscillations that were synchronized across the hippocampus and cortex. Furthermore, the hippocampal-cortical interactions increased during the narrow time-window of the peak cAMP level; suppressing hippocampal activity specifically during this window impaired spatial memory consolidation. Thus, hippocampal-dependent memory consolidation occurs within a specific time window of high cAMP activity during slow-wave sleep.
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