The PhD student will be part of the ANR project 'REFINED' involving the Laboratory of Embedded Artificial Intelligence in CEA List in Paris, the Multispeech research team In LORIA, Nancy, and the Hearing Institute in Paris. The project aims at studying new Deep Learning based methods to improve hearing acuity of ANSD patients. A cohort of ANSD volunteers will be tested to identify spectro-temporal auditory and extra-auditory cues correlated with the speech perception. Additionally, the benefits of neural networks will be studied. However, current artificial intelligence methods are too complex to be applied to processors with low computing and memory capacities: compression and optimization methods are needed.

Myopia is predicted to affect 50% of all people worldwide by 2050, and is a risk factor for significant, potentially blinding ocular pathologies, such as retinal detachment and glaucoma. Thus, there is significant motivation to better understand the process of myopigenesis and to develop effective anti-myopigenic treatments. In nearly all cases of human myopia, scleral remodeling is an obligate step in the axial elongation that characterizes the condition. Here I will describe the development of a biomechanical assay based on transient unconfined compression of scleral samples. By treating the scleral as a poroelastic material, one can determine scleral biomechanical properties from extremely small samples, such as obtained from the mouse eye. These properties provide proxy measures of scleral remodeling, and have allowed us to identify all-trans retinoic acid (atRA) as a myopigenic stimulus in mice. I will also describe nascent collaborative work on modeling the transport of atRA in the eye.