TopicNeuroscience

autophagy

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43Total items

39ePosters

4Seminars

Latest

SeminarNeuroscience

‘Autophagy regulates neurotransmission by controlling the axonal endoplasmic reticulum’

Marijn Kuijpers

Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin

Feb 17, 2022

SeminarNeuroscience

How does a neuron decide when and where to make a synapse?

Peter R. Hiesinger

Free University, Berlin, Germany

Feb 16, 2022

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. How does genetically encoded brain wiring deal with this apparent contradiction? Brain wiring is a developmental growth process that is not only characterized by precision, but also flexibility and robustness. As in any other growth process, cellular interactions are restricted in space and time. Correspondingly, molecular and cellular interactions are restricted to those that 'get to see' each other during development. This seminar will explore the question how neurons decide when and where to make synapses using the Drosophila visual system as a model. New findings reveal that pattern formation during growth and the kinetics of live neuronal interactions restrict synapse formation and partner choice for neurons that are not otherwise prevented from making incorrect synapses in this system. For example, cell biological mechanisms like autophagy as well as developmental temperature restrict inappropriate partner choice through a process of kinetic exclusion that critically contributes to wiring specificity. The seminar will explore these and other neuronal strategies when and where to make synapses during developmental growth that contribute to precise, flexible and robust outcomes in brain wiring.

SeminarNeuroscience

Neuronal autophagy promotes the hormonal regulation of brain cognitive and metabolic functions

Franck Oury

Institut Necker Enfants-Malades (INEM) - University of Paris - INSERM U1151

Sep 23, 2021

SeminarNeuroscience

Targeting selective autophagy against neurodegenerative diseases

Ana Maria Cuervo

Albert Einstein College of Medicine, New York, USA

Apr 21, 2021

Protein quality control is essential for maintenance of a healthy and functional proteome that can attend the multiplicity of cellular functions. Failure of the systems that contribute to protein homeostasis, the so called proteostasis networks, have been identified in the pathogenesis of multiple neurodegenerative disorders and demonstrated to contribute to disease onset and progression. We are interested in autophagy, one of the components of the proteostasis network, and in the interplay of wo selective types of autophagy, chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI), with neurodegeneration. We have recently found that pathogenic proteins involved in common neurodegenerative conditions such as tauopathies or Parkinson’s disease, can exert a toxic effect in both types of selective types of autophagy compromising their functioning. We have now used mouse models with compromised CMA that support increased propagation of proteins such as tau and alpha-synuclein and an exacerbation of disease phenotype with aging. Conversely, genetic or chemical upregulation of CMA in this context of proteotoxicity slow down disease progression by facilitating effective intracellular removal of pathogenic proteins. Our findings highlight CMA and eMI as potential novel therapeutic targets against neurodegeneration.

autophagy

Latest

‘Autophagy regulates neurotransmission by controlling the axonal endoplasmic reticulum’

How does a neuron decide when and where to make a synapse?

Neuronal autophagy promotes the hormonal regulation of brain cognitive and metabolic functions

Targeting selective autophagy against neurodegenerative diseases

ATP6V1A, a key player for lysosomal function and autophagy process, is required for neuronal development and synaptic plasticity

Autophagy and ESCRT machinery impairment and lysosomal damage in frontal cortex and hippocampus of rats in a depression-like model

Autophagy and neurodevelopmental disorders 2 : Ultrasonic vocalization (USV) and social interaction from preweaning up to adult Irgm1-ko mice

Autophagy and neurodevelopmental disorders 1 : Sensory motor development in preweaning Irgm1-ko mice

Contribution of GBA1 mutations to autophagy-lysosomal pathway in Parkinson's disease

Identifying deregulated autophagy as underlying mechanism of neurodevelopmetnal disorders

Inhibition of Neuronal Autophagy Contributes to Reduced Ischemic Brain Damage in rats

Interplay between Lewy pathology and macroautophagy in midbrain dopaminergic neurons in vivo

Modulation of anandamide tone as an effective strategy for in vitro and in vivo stimulation of autophagy in Alzheimer's disease

The NMDA receptor triggers neuronal autophagy during Oxygen and Glucose Deprivation

Priming mesenchymal stem cells with α-synuclein enhances neuroprotective properties through induction of autophagy in Parkinsonian models

Regulation of the apoptosis/autophagy switch by propionic acid in ventromedial hypothalamus of rats with type 2 diabetes mellitus

Regulation of Neuronal Autophagy by Endocytic Kinase AAK1

The role of autophagy in parvalbumin-expressing neurons

Role of the neuronal primary cilia-autophagy axis in the regulation of cognition during aging

The Serum Response Factor (SRF) regulates motoneuron vulnerability in ALS through the regulation of autophagy flux

SIRT1-dependent autophagy as a novel therapy for age-related memory decline

TBC1D24 interacts with v-ATPase and regulates pH homeostasis and autophagy in neurons

Activation of non-nuclear estrogen receptor signaling pathways with PaPE-1 as a potential remedy for amyloid-beta induced toxicity: Impact on autophagy

Altered autophagy in KANSL1 haploinsufficient iPSC-derived astrocytes

Autophagy modulation of glial neuroinflammatory responses in Parkinson’s disease

Autophagy regulation during brain development and synaptogenesis

Chaperone mediated autophagy is deficient in spinal motoneurons of ALS patients

Dissecting the role of autophagy to elucidate the differential response of oligodendrocytes and astrocytes to hypoxic injury in vitro

Effect of melatonin on the autophagy in the prefrontal cortex of streptozotocin-induced type 1 diabetic rats

Identification of sex-specific autophagy enhancers for dementia

Impaired macroautophagy in oligodendrocyte precursor cells exacerbates aging-related cognitive deficits via a senescence-associated signaling

Infantile ceroid neuro-lipofuscinosis: Linking autophagy, altered chloride homeostasis, and enhanced brain excitability

Interplay between tubulin tyrosination, autophagy and neuron health

Longitudinal autophagy profiling of mammalian brain circuits reveals dynamic and sustained mitophagy throughout healthy aging

Neuroprotective effect of bicifadine, sertraline, and tiagabine with autophagy-inducing activity in 6-hydroxydopamine Parkinson’s models

A novel role for autophagy protein WIPI2 in cognitive fitness

Pharmacological stimulation of autophagy to rescue proteinopathy and cognitive decline in lysosomal storage disorders

Rab5-associated transcriptome reveals a new link between endosomes and autophagy in axons

Role of late endosomal autophagy-dependent secretion in neurodegeneration

The serine-threonine kinase Ndr2 impairs spatial memory and regulates autophagy and protein expression in the synapses of the ageing hippocampus

Testing the therapeutic effects of autophagy enhancement in a Rett syndrome mouse model

TFEB-loaded exosomes mediated autophagy induction in Alzheimer’s disease

Tibolone improves locomotor function in a rat model of spinal cord injury by modulating apoptosis and autophagy