TopicNeuroscience

autophagy

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44Total items

40ePosters

4Seminars

Latest

SeminarNeuroscience

‘Autophagy regulates neurotransmission by controlling the axonal endoplasmic reticulum’

Marijn Kuijpers

Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin

Feb 17, 2022

SeminarNeuroscience

How does a neuron decide when and where to make a synapse?

Peter R. Hiesinger

Free University, Berlin, Germany

Feb 16, 2022

Precise synaptic connectivity is a prerequisite for the function of neural circuits, yet individual neurons, taken out of their developmental context, readily form unspecific synapses. How does genetically encoded brain wiring deal with this apparent contradiction? Brain wiring is a developmental growth process that is not only characterized by precision, but also flexibility and robustness. As in any other growth process, cellular interactions are restricted in space and time. Correspondingly, molecular and cellular interactions are restricted to those that 'get to see' each other during development. This seminar will explore the question how neurons decide when and where to make synapses using the Drosophila visual system as a model. New findings reveal that pattern formation during growth and the kinetics of live neuronal interactions restrict synapse formation and partner choice for neurons that are not otherwise prevented from making incorrect synapses in this system. For example, cell biological mechanisms like autophagy as well as developmental temperature restrict inappropriate partner choice through a process of kinetic exclusion that critically contributes to wiring specificity. The seminar will explore these and other neuronal strategies when and where to make synapses during developmental growth that contribute to precise, flexible and robust outcomes in brain wiring.

SeminarNeuroscience

Neuronal autophagy promotes the hormonal regulation of brain cognitive and metabolic functions

Franck Oury

Institut Necker Enfants-Malades (INEM) - University of Paris - INSERM U1151

Sep 23, 2021

SeminarNeuroscience

Targeting selective autophagy against neurodegenerative diseases

Ana Maria Cuervo

Albert Einstein College of Medicine, New York, USA

Apr 21, 2021

Protein quality control is essential for maintenance of a healthy and functional proteome that can attend the multiplicity of cellular functions. Failure of the systems that contribute to protein homeostasis, the so called proteostasis networks, have been identified in the pathogenesis of multiple neurodegenerative disorders and demonstrated to contribute to disease onset and progression. We are interested in autophagy, one of the components of the proteostasis network, and in the interplay of wo selective types of autophagy, chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI), with neurodegeneration. We have recently found that pathogenic proteins involved in common neurodegenerative conditions such as tauopathies or Parkinson’s disease, can exert a toxic effect in both types of selective types of autophagy compromising their functioning. We have now used mouse models with compromised CMA that support increased propagation of proteins such as tau and alpha-synuclein and an exacerbation of disease phenotype with aging. Conversely, genetic or chemical upregulation of CMA in this context of proteotoxicity slow down disease progression by facilitating effective intracellular removal of pathogenic proteins. Our findings highlight CMA and eMI as potential novel therapeutic targets against neurodegeneration.

autophagy

Latest

‘Autophagy regulates neurotransmission by controlling the axonal endoplasmic reticulum’

How does a neuron decide when and where to make a synapse?

Neuronal autophagy promotes the hormonal regulation of brain cognitive and metabolic functions

Targeting selective autophagy against neurodegenerative diseases

THE SERINE-THREONINE KINASE NDR2 IMPAIRS SPATIAL MEMORY THROUGH AN INTERPLAY OF AUTOPHAGY AND PROTEOSTASIS IN OF THE AGEING HIPPOCAMPUS

WIPI2 PHOSPHORYLATION MEDIATES EARLY INTRA-AXONAL AUTOPHAGY DYSFUNCTION IN ALZHEIMER’S DISEASE

LONGITUDINAL AUTOPHAGY PROFILING OF THE MAMMALIAN BRAIN REVEALS SUSTAINED MITOPHAGY THROUGHOUT HEALTHY AGING

AUTOPHAGY-LYSOSOMAL PATHWAY PROTEINS IN DERMAL FIBROBLASTS AS POTENTIAL PERIPHERAL BIOMARKERS FOR ALZHEIMER'S DISEASE DIAGNOSIS

HYPERAMMONEMIA INCREASES THE RELEASE OF PATHOLOGICAL EXTRACELLULAR VESICLES FROM MONOCYTES BY IMPAIRING LYSOSOMAL FUNCTION AND AUTOPHAGY THROUGH THE TNFΑ–CAMP–PKA–LC3 PATHWAY

DEVELOPING CELL-BASED BIOASSAYS FOR CLINICAL TRIALS – THE USE OF PATIENT-DERIVED INDUCED NEURONS TO STUDY AUTOPHAGY IN THE FELL-HD CLINICAL TRIAL

ORGANELLE CALCIUM CHANNEL INTEGRATES INTRACELLULAR SIGNALS INTO AUTOPHAGY PATHWAYS

AUTOPHAGY-DEPENDENT MECHANISMS IN OLIGODENDROCYTE MATURATION AND WHITE MATTER INTEGRITY

DISTINCT TAU ISOFORMS DIFFERENTIALLY DISRUPT AUTOPHAGY AND MITOCHONDRIAL FUNCTION: IMPLICATIONS FOR TAUOPATHIES

TECPR2 DEFICIENCY INDUCES AXONAL AUTOPHAGY DYSREGULATION IN HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE IX

INTRANASAL DELIVERY OF HELICURE REDUCES Α-SYNUCLEIN OLIGOMERS, ALTERS AUTOPHAGY MECHANISMS, AND RESCUES MOTOR DEFICITS IN A PARKINSON’S DISEASE MOUSE MODEL

E159, A HISTAMINE H3 RECEPTOR ANTAGONIST, AMELIORATES ASD-RELATED BEHAVIOURS BY ENHANCING AUTOPHAGY AND HIPPOCAMPAL NEUROGENESIS IN BTBR MICE

NEURONAL AUTOPHAGY AS A REGULATOR OF FEEDING BEHAVIOR: THE ROLE OF <EM>EGLI-1 </EM>IN <EM>C. ELEGANS</EM>

EXOSOME-MEDIATED TFEB DELIVERY ENHANCES AUTOPHAGY IN ALZHEIMER’S DISEASE

ROLE OF THE SERINE-THREONINE KINASE NDR2 IN NEURONAL PRIMARY CILIA FORMATION AND AUTOPHAGY

STUDYING NEURONAL AUTOPHAGY IN HUMAN AGEING USING INDUCED NEURONS DIRECTLY REPROGRAMMED FROM ADULT HUMAN DERMAL FIBROBLASTS

TARGETING MALAT1 LNCRNA TO MODULATE AUTOPHAGY AND MYOGENESIS IN IPSC-DERIVED MUSCLE CELLS: A NANO-NUCLEAR STRATEGY FOR C9ORF72-ALS

HOW DOES AUTOPHAGY COPE WITH SPECIFIC SYNAPTIC NEEDS? CONSEQUENCES IN BRAIN HEALTH AND DISEASE

CROSS-SPECIES IN VIVO IMAGING REVEALS AUTOPHAGY DYNAMICS DURING SLEEP AND WAKEFULNESS

SHARING IS CARING - ASTROCYTES FACILITATE NEURONAL AUTOPHAGY

BETA-HYDROXYBUTYRATE STIMULATES THE AUTOPHAGY-LYSOSOMAL AXIS IN ASTROCYTES

Autophagy regulation during brain development and synaptogenesis

Chaperone mediated autophagy is deficient in spinal motoneurons of ALS patients

Dissecting the role of autophagy to elucidate the differential response of oligodendrocytes and astrocytes to hypoxic injury in vitro

Effect of melatonin on the autophagy in the prefrontal cortex of streptozotocin-induced type 1 diabetic rats

Identification of sex-specific autophagy enhancers for dementia

Impaired macroautophagy in oligodendrocyte precursor cells exacerbates aging-related cognitive deficits via a senescence-associated signaling

Infantile ceroid neuro-lipofuscinosis: Linking autophagy, altered chloride homeostasis, and enhanced brain excitability

Interplay between tubulin tyrosination, autophagy and neuron health

Longitudinal autophagy profiling of mammalian brain circuits reveals dynamic and sustained mitophagy throughout healthy aging

Neuroprotective effect of bicifadine, sertraline, and tiagabine with autophagy-inducing activity in 6-hydroxydopamine Parkinson’s models

A novel role for autophagy protein WIPI2 in cognitive fitness

Pharmacological stimulation of autophagy to rescue proteinopathy and cognitive decline in lysosomal storage disorders

Rab5-associated transcriptome reveals a new link between endosomes and autophagy in axons

Role of late endosomal autophagy-dependent secretion in neurodegeneration

ATP6V1A, a key player for lysosomal function and autophagy process, is required for neuronal development and synaptic plasticity

Testing the therapeutic effects of autophagy enhancement in a Rett syndrome mouse model

TFEB-loaded exosomes mediated autophagy induction in Alzheimer’s disease

Tibolone improves locomotor function in a rat model of spinal cord injury by modulating apoptosis and autophagy

The serine-threonine kinase Ndr2 impairs spatial memory and regulates autophagy and protein expression in the synapses of the ageing hippocampus