REM sleep

Neural circuits underlying sleep structure and functions

Sleep is an active state critical for processing emotional memories encoded during waking in both humans and animals. There is a remarkable overlap between the brain structures and circuits active during sleep, particularly rapid eye-movement (REM) sleep, and the those encoding emotions. Accordingly, disruptions in sleep quality or quantity, including REM sleep, are often associated with, and precede the onset of, nearly all affective psychiatric and mood disorders. In this context, a major biomedical challenge is to better understand the underlying mechanisms of the relationship between (REM) sleep and emotion encoding to improve treatments for mental health. This lecture will summarize our investigation of the cellular and circuit mechanisms underlying sleep architecture, sleep oscillations, and local brain dynamics across sleep-wake states using electrophysiological recordings combined with single-cell calcium imaging or optogenetics. The presentation will detail the discovery of a 'somato-dendritic decoupling'in prefrontal cortex pyramidal neurons underlying REM sleep-dependent stabilization of optimal emotional memory traces. This decoupling reflects a tonic inhibition at the somas of pyramidal cells, occurring simultaneously with a selective disinhibition of their dendritic arbors selectively during REM sleep. Recent findings on REM sleep-dependent subcortical inputs and neuromodulation of this decoupling will be discussed in the context of synaptic plasticity and the optimization of emotional responses in the maintenance of mental health.

REM sleep and the energy allocation hypothesis”

How sleep contributes to visual perceptual learning

Sleep is crucial for the continuity and development of life. Sleep-related problems can alter brain function, and cause potentially severe psychological and behavioral consequences. However, the role of sleep in our mind and behavior is far from clear. In this talk, I will present our research on how sleep may play a role in visual perceptual learning (VPL) by using simultaneous magnetic resonance spectroscopy and polysomnography in human subjects. We measured the concentrations of neurotransmitters in the early visual areas during sleep and obtained the excitation/inhibition (E/I) ratio which represents the amount of plasticity in the visual system. We found that the E/I ratio significantly increased during NREM sleep while it decreased during REM sleep. The E/I ratio during NREM sleep was correlated with offline performance gains by sleep, while the E/I ratio during REM sleep was correlated with the amount of learning stabilization. These suggest that NREM sleep increases plasticity, while REM sleep decreases it to solidify once enhanced learning. NREM and REM sleep may play complementary roles, reflected by significantly different neurochemical processing, in VPL.

Active sleep in flies: the dawn of consciousness

The brain is a prediction machine. Yet the world is never entirely predictable, for any animal. Unexpected events are surprising and this typically evokes prediction error signatures in animal brains. In humans such mismatched expectations are often associated with an emotional response as well. Appropriate emotional responses are understood to be important for memory consolidation, suggesting that valence cues more generally constitute an ancient mechanism designed to potently refine and generalize internal models of the world and thereby minimize prediction errors. On the other hand, abolishing error detection and surprise entirely is probably also maladaptive, as this might undermine the very mechanism that brains use to become better prediction machines. This paradoxical view of brain functions as an ongoing tug-of-war between prediction and surprise suggests a compelling new way to study and understand the evolution of consciousness in animals. I will present approaches to studying attention and prediction in the tiny brain of the fruit fly, Drosophila melanogaster. I will discuss how an ‘active’ sleep stage (termed rapid eye movement – REM – sleep in mammals) may have evolved in the first animal brains as a mechanism for optimizing prediction in motile creatures confronted with constantly changing environments. A role for REM sleep in emotional regulation could thus be better understood as an ancient sleep function that evolved alongside selective attention to maintain an adaptive balance between prediction and surprise. This view of active sleep has some interesting implications for the evolution of subjective awareness and consciousness.

Neural mechanisms for memory and emotional processing during sleep

The hippocampus and the amygdala are two structures required for emotional memory. While the hippocampus encodes the contextual part of the memory, the amygdala processes its emotional valence. During Non-REM sleep, the hippocampus displays high frequency oscillations called “ripples”. Our early work shows that the suppression of ripples during sleep impairs performance on a spatial task, underlying their crucial role in memory consolidation. We more recently showed that the joint amygdala-hippocampus activity linked to aversive learning is reinstated during the following Non-REM sleep epochs, specifically during ripples. This mechanism potentially sustains the consolidation of aversive associative memories during Non REM sleep. On the other hand, REM sleep is associated with regular 8 Hz theta oscillations, and is believed to play a role in emotional processing. A crucial, initial step in understanding this role is to unravel sleep dynamics related to REM sleep in the hippocampus-amygdala network

Sleep, semantic memory, and creative problem solving

Creative thought relies on the reorganisation of existing knowledge. Sleep is known to be important for creative thinking, but there is a debate about which sleep stage is most relevant, and why. I will address this issue by proposing that Rapid Eye Movement sleep, or 'REM', and Non-REM sleep facilitate creativity in different ways. Memory replay mechanisms in Non-REM can abstract rules from corpuses of learned information, while replay in REM may promote novel associations. I propose that the iterative interleaving of REM and Non-REM across a night boosts the formation of complex knowledge frameworks, and allows these frameworks to be restructured - thus facilitating creative thought. My talk will discuss experiments exploring these hypotheses, and the mechanisms for these processes.

REM and Non-REM sleep-dependent neural dynamics in the hippocampus-amygdala network

A neuronal central pattern generator to control the REM/non-REM sleep cycle

Bernstein Conference 2024

Hippocampal Neocortical Coupling Varies as a Function of Depth of NREM Sleep

COSYNE 2022

Hippocampal Neocortical Coupling Varies as a Function of Depth of NREM Sleep

COSYNE 2022

Orienting eye movements during REM sleep

COSYNE 2022

Orienting eye movements during REM sleep

COSYNE 2022

Hippocampal Neocortical Coupling Varies as a Function of Depth of NREM Sleep

COSYNE 2023

40-Hz stimulation during NREM sleep induces a specific auditory steady-state response and an increase in the sleep-spindle power associated with up and down cortical states

Absence-seizure blockade rescues REM sleep impairment in a rat model of SYNGAP1 haploinsufficiency

"Controlling the gates" of REM sleep: dual muscarinic-nicotinic modulation of GABAergic transmission at the REM-S executive area

Coupling during NREM sleep between the prelimbic cortex, nucleus reuniens, and hippocampus remains stable under cognitive and ho-meostatic demands

Hippocampal sleep spindle dynamics during REM sleep and their distinct underlying parvalbumin and synaptic proteins expression in the reticulo-thalamic nucleus of the parkinsonian rats

Increased cortical plasticity enhances one-trial memory but leads to increased interference of semantic-like memory and changes in NonREM sleep oscillations in rats

The integration of skin and core body temperature in the expression of REM sleep and the role of the hypothalamus

Learning fast and slow: the effect of increased cortical plasticity on the prefrontal-hippocampal communication during wake and REM sleep states

The Locus Coeruleus is a gate for NREM-to-REM sleep transitions

Paradoxical somato-dendritic decoupling supports cortical plasticity during REM sleep

The Role of the Melanin Concentrating hormone (MCH) system in Increased REM Sleep Propensity and Cataplexy in Narcolepsy

A Role for Orexin in REM Sleep Regulation

Spectral power and temporal coupling of the EEG during REM sleep in patients with frontal brain tumor

Effects of chemogenetic inhibition of mesopontine cholinergic neurons on REM sleep and PGO waves in mice

FENS Forum 2024

Effect of open-loop auditory stimulus during NREM sleep among youth & geriatric subjects: A comparative nap study

FENS Forum 2024

Electrophysiological recording of the activity of a novel subtype of REM sleep regulating neurons across the sleep/wake cycle

FENS Forum 2024

Evidence for central-pattern-generator circuits driving the REM-NREM sleep cycle

FENS Forum 2024

GABAergic neurons in the rostromedial tegmental nucleus mediate transitions from REM sleep to arousal in mice

FENS Forum 2024

Glutamatergic neurons in the subthalamic nucleus regulate arousal and REM sleep

FENS Forum 2024

Identification of a subpopulation of neurons in the brainstem pons whose activation increases NREM sleep

FENS Forum 2024

The impact of memory consolidation on REM sleep architecture in rodents: An insight into phasic and tonic substates

FENS Forum 2024

Modulation of NREM sleep by corticotropin-releasing hormone through the thalamic reticular nucleus

FENS Forum 2024

Noradrenergic locus coeruleus activity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle

FENS Forum 2024

Somato-dendritic decoupling in the retrosplenial cortex neurons during REM sleep

FENS Forum 2024