TLR4

Converging mechanisms of epileptogenesis after brain injury

Traumatic brain injury (TBI), a leading cause of acquired epilepsy, results in primary cellular injury as well as secondary neurophysiological and inflammatory responses which contribute to epileptogenesis. I will present our recent studies identifying a role for neuro-immune interactions, specifically, the innate immune receptor Toll-like receptor 4 (TLR4), in enhancing network excitability and cell loss in hippocampal dentate gyrus early after concussive brain injury. I will describe results indicating that the transient post-traumatic increases in dentate neurogenesis which occurs during the same early post-injury period augments dentate network excitability and epileptogenesis. I will provide evidence for the beneficial effects of targeting TLR4 and neurogenesis early after brain injury in limiting epileptogenesis. We will discuss potential mechanisms for convergence of the post-traumatic neuro-immune and neurogenic changes and the implications for therapies to reduce neurological deficits and epilepsy after brain injury.

ENTERIC GLIAL INFLAMMATION IN EARLY PARKINSON’S DISEASE: MODULATORY EFFECTS OF RAS INHIBITORS ON TLR4/NLRP3 SIGNALING THROUGH INTEGRATED <EM >IN VITRO</EM> AND <EM>IN SILICO</EM> ANALYSIS

FENS Forum 2026

SPIKE PROTEIN DRIVES SYNAPTIC DEFICITS AND INFLAMMATORY MICROGLIA THROUGH A TLR4-DEPENDENT MECHANISM IN HIPPOCAMPAL SLICES

FENS Forum 2026

OMEGA-3 SUPPLEMENTATION MODULATES STRESS-INDUCED INCREASE IL-6 AND TLR4 GENE EXPRESSION

FENS Forum 2026

Toll-Like Receptor 4 (TLR4), a target for cytoprotection and (re)myelination in multiple sclerosis

FENS Forum 2024

Systemic lipopolysaccharide exposure triggers Tlr4-dependent inflammatory responses in the mouse retina in vivo

Alogliptin Attenuates Lipopolysaccharide-Induced Neuroinflammation in Mice Through Modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 Signaling Pathways

Role of TLR4 pathway in the prefrontal cortex following acute and chronic administration of morphine and its withdrawal syndrome

FENS Forum 2024