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ANTIBIOTIC-MEDIATED GUT MICROBIOTA DEPLETION DISRUPTS BEHAVIORAL AND NEURONAL CORRELATES OF SPATIAL COGNITION
Jordi Chanovas Coloméand 2 co-authors
School of Graduate Studies, Graduate Program in Neural and Behavioral Sciences, State University of New York, Downstate Health Sciences University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-543
Presentation
Date TBA
Board: PS05-09AM-543
Event Information
Poster Board
PS05-09AM-543
Poster
View posterAbstract
Trillions of microbes —comprising communities of bacteria, viruses, fungi, and other microorganisms— inhabit the gastrointestinal tract. Known as gut microbiota, these microorganisms are central to human health. Growing evidence connects imbalances of microbial communities with several neurological and psychiatric conditions, and signals to the modulating role of gut bacteria on brain function, including learning and memory. However, how the microbiota influences cognitive behavior remains unclear. Here, we investigated whether gut microbiota depletion disrupts the behavioral and neuronal correlates of spatial cognition. We depleted gut bacteria in adult mice by giving a cocktail of non-absorbable antimicrobials and characterized 1) learning and memory performance in modalities of a place avoidance task with different cognitive demands and 2) Arc and c-Fos-expressing neuronal ensembles in the supra and infrapyramidal blades of the dentate gyrus. We found that microbiota depletion selectively impaired cognitive control in place avoidance tasks and identified a molecular correlate of this deficit — a loss of Arc/c-Fos asymmetry between the blades of the dentate gyrus. Our results suggest that gut microbial signaling may contribute to hippocampal ensemble organization underlying spatial processing and cognitive control.
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