Poster preview
ePoster
THE MATERNAL GUT MICROBIOTA REGULATES EMBRYONIC CORTICAL DEVELOPMENT IN MICE
Hugo Blairand 10 co-authors
University College Cork
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-552
Presentation
Date TBA
Board: PS05-09AM-552
Event Information
Poster Board
PS05-09AM-552
Poster
View posterAbstract
Whilst embryonic neurodevelopment occurs in a uterine environment free from host microbial influence, recent evidence suggests that microbial signals originating from the maternal gut microbiota may play a regulatory role. We hypothesised this may occur through microbial signalling during prenatal development to radial glial (RG) cells, which generate cortical neurons and glia, and function as a scaffold along which new-born neurons migrate. Therefore we aimed to study the effect of maternal gut microbiota depletion during gestation on RG-led neurodevelopment in the cerebral cortex. We collected E15.5/E18.5 embryonic offspring, either from female mice treated with an antibiotic cocktail prior to and throughout gestation, or from germ free mice, and examined aspects of neurodevelopment via immunofluorescence. Embryonic cerebrospinal fluid (CSF) and maternal plasma were also collected for metabolomic analysis via ultra performance liquid chromatography-mass spectrometry. Depletion of the gestational maternal gut microbiota affected embryonic RG-led neurodevelopment, with both sex- and region-dependent alterations seen in the number of radial glial and intermediate progenitors, and in derived layer-specific excitatory neurons. Changes were also seen in radial glial proliferation and apical structure. Finally, maternal antibiotic treatment altered the metabolomic profile of both the maternal plasma and embryonic CSF, pointing to the CSF as a reservoir for maternally derived microbial signals. In conclusion, we identified that an absence of microbial signals prenatally alters radial glial-led cortical neurodevelopment, which may be explained by changes in key metabolites.
Recommended posters
THE MATERNAL GUT MICROBIOTA SHAPES NEUROVASCULAR DEVELOPMENT IN MICE
Alexandre Cergneux, Valentine Turpin, Jennifer Morael, Lorena Morales, Hugo Blair, Federico Granziera, Emily G. Knox, Verónica Arreaza-Gil, Elisa Cintado, Jennifer Shearer, John F. Cryan, María R. Aburto
IMPACT OF GUT-MICROBIOTA-DERIVED INDOLE COMPOUNDS ON EARLY BRAIN DEVELOPMENT IN MICE
Maëva Rebion, Elise Miller, Elise Maximin, Mélanie Sirigu, Ninon Doniol-Valcroze, Cassandre Morel, Isabelle Grit, Guillaume De Lartigue, Arashdeep Singh, Catherine Michel, Gwenola Le Dréan, Odile Tresse, Patricia Parnet, Laurent Naudon, Sylvie Rabot, Vincent Paillé
GUT DYSBIOSIS-INDUCED MODULATION OF MICROGLIAL MORPHOLOGY AND FUNCTION
Isabell Haack, Krishnapriya Krishnapriya, Rishikesh Rishikesh, Dayamrita Kollaparampil Kishanchand, Shirin Hosseini, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Korte
MATERNAL TRANSFER OF AUTISM-ASSOCIATED MICROBIOTA INDUCES SEX-SPECIFIC HIPPOCAMPAL TRANSCRIPTOMIC ALTERATIONS IN MOUSE OFFSPRING
Arnas Kunevičius, Giancarlo Russo, Eric Daliri, Dominykas Varnas, Vaidotas Urbonas, Aurelijus Burokas
MICROBIOTA–MICROGLIA INTERACTIONS IN HUMAN CORTICAL CIRCUITS FUNCTION AND EPILEPTIC DISORDER
Yashita Rungoo, Mariagiovanna Di Chiano, Yiannis Poulot-Becq-Giraudon, Vivien Letenneur, Maria Teresa Rocchetti, Daniela Fiocco, Giuseppe Spano, Thomas Blauwblomme, Giampaolo Milior
JUVENILE GUT DYSBIOSIS INDUCES MICROGLIAL ACTIVATION, SELECTIVE POSTSYNAPTIC PRUNING, REGION-SPECIFIC METABOLIC SHIFTS, AND ANXIETY-LIKE BEHAVIOURS IN MICE
Dayamrita K K, Krishnapriya Krishnapriya, Rishikesh Rishikesh, Deepa A V, Shubham Upadhyay, T S Keshava Prasad, Isabell Haack, Shirin Hosseini, Unnikrishnan Sivan, Martin Korte, Baby Chakrapani P S