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ePoster
ANTIBIOTIC TREATMENT-INDUCED MICROBIOME DISRUPTION HAS POSITIVE EFFECT ON PTSD-LIKE BEHAVIOUR IN AN ELECTRIC FOOTSHOCK MODEL IN MICE
Prabhat Kumarand 4 co-authors
Institute of Physiology, Medical School, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-314
Presentation
Date TBA
Board: PS04-08PM-314
Event Information
Poster Board
PS04-08PM-314
Poster
View posterAbstract
Introduction: Emerging evidence implicates the gut-brain axis as a critical modulator of stress-related psychopathology; however, the temporal specificity by which gut perturbations interact with trauma to shape fear memory remains poorly defined.
Aim: In male CD1 mice footshock-induced trauma was used as a model of posttraumatic stress disorder (PTSD) and freezing as major parameter was assessed. Antibiotic cocktail (AB) was given into the drinking water with different timing. The animals were evaluated 24h (acute stress disorder, ASD) and 14 days (PTSD-like) after trauma.
Methods & Results: Pretrauma AB treatment for 14 days was able to reduce both ASD and PTSD-like behvaiour. However, this effect became significant only in comparison with water treated group. Sweetener, used to make AB cocktail more palatable, has similar, PTSD normalizing effect. This effect was, however, visible only in case sweetener was applied continuously, i.e., after trauma, while when sweetener was applied only before trauma, this treatment was ineffective. A more prolonged AB pretreatment for 28 days before trauma influenced PTSD-like freezing. In this case the sweetener was applied only before trauma.
Conclusion: Our works highlight positive effect of dietary intervention direct after trauma and emphasize their interaction with ABs in shaping the gut microbiome.
Aim: In male CD1 mice footshock-induced trauma was used as a model of posttraumatic stress disorder (PTSD) and freezing as major parameter was assessed. Antibiotic cocktail (AB) was given into the drinking water with different timing. The animals were evaluated 24h (acute stress disorder, ASD) and 14 days (PTSD-like) after trauma.
Methods & Results: Pretrauma AB treatment for 14 days was able to reduce both ASD and PTSD-like behvaiour. However, this effect became significant only in comparison with water treated group. Sweetener, used to make AB cocktail more palatable, has similar, PTSD normalizing effect. This effect was, however, visible only in case sweetener was applied continuously, i.e., after trauma, while when sweetener was applied only before trauma, this treatment was ineffective. A more prolonged AB pretreatment for 28 days before trauma influenced PTSD-like freezing. In this case the sweetener was applied only before trauma.
Conclusion: Our works highlight positive effect of dietary intervention direct after trauma and emphasize their interaction with ABs in shaping the gut microbiome.
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