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EFFECT OF ARIPIPRAZOLE /PROBIOTICS TREATMENT ON MICROBIOTA AND BEHAVIOR IN AN ANIMAL MODEL OF PTSD
Jana Osackaand 5 co-authors
Biomedical Research Center of the Slovak Academy of Sciences, Institute of Experimental Endocrinology
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-553
Presentation
Date TBA
Board: PS01-07AM-553
Event Information
Poster Board
PS01-07AM-553
Poster
View posterAbstract
Post-traumatic stress disorder (PTSD) is associated with dysregulation of the hypothalamic–pituitary–adrenal axis, leading to alterations in behavior, immune function, and the gut microbiota. Atypical antipsychotics, including aripiprazole (ARI), and probiotics alleviate PTSD-related disturbances. The aim of the present study was to investigate whether probiotic modulation of the microbiota enhances the therapeutic effects of ARI and more effectively attenuates adverse behavioral and physiological changes associated with PTSD in a single prolonged stress (SPS) animal model.
ARI was administered i.p. (3 mg/kg), and probiotic Lactibiane—comprising 4 bacterial species (Bifidobacterium longum, Lactobacillus helveticus, Lactococcus lactis, and Streptococcus thermophilus) in drinking water (1 × 10⁹ CFU/day) for 28 days. Anxiety-like and hedonic behaviors were assessed, and selected bacterial populations in fecal samples and spleen tissue were analyzed using 16S rRNA gene sequencing.
In fecal samples, SPS altered the bacterial community composition, and probiotic treatment increased the abundance of Lactobacillus. SPS induced anxiety-like behavior, which was not reversed by either ARI or Lactibiane. Anxiety-like behavior correlated with Lactobacillus and Bacteroidetes 16S rRNA abundance in the spleen. In contrast, Lactibiane administered alone or in combination with ARI suppressed hedonic behavior. SPS reduced plasma corticosterone (CORT) and lipopolysaccharide-binding protein levels, and these effects were not reversed by ARI or Lactibiane. Plasma CORT levels correlated with spleen total bacterial 16S rRNA abundance.
Present findings do not support potentiating effect of Lactibiane on ARI treatment in SPS model of PTSD but highlight the involvement of the gut–spleen–brain axis in PTSD pathophysiology.
Supported by APVV-24-0213.
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