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EXPLORING THE INTERPLAY BETWEEN THE EXTRASYNAPTIC SURFACEOME AND EXTRACELLULAR MATRIX IN HIPPOCAMPAL NETWORKS
Camille Mergauxand 4 co-authors
CNRS
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-010
Presentation
Date TBA
Board: PS01-07AM-010
Event Information
Poster Board
PS01-07AM-010
Poster
View posterAbstract
Neurotransmitter receptors, and more generally membrane proteins, are organized along the surface of neurons in a structured manner. Neurons are enwrapped in a dense mesh of proteins and polysaccharides, namely the extracellular matrix (ECM), that control several key functions such as synaptic development and plasticity. Yet, the molecular mechanisms by which the ECM structure membrane proteins and their signaling function remain poorly understood. Here, we investigated how ECM controls surface proteins (surfaceome) organization and related functions using a combination of single molecule localization and tracking microscopy approaches (dSTORM, sptPALM). We report that extrasynaptic surface proteins are organized within nanoscale complexes whose organization is tuned by ECM in a bi-directional way. Specific neurotransmitter receptors were investigated, confirming such ECM-membrane protein interplay. Thus, we propose that the ECM is an important regulatory actor of the neuronal membrane surfaceome.
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