Poster preview
ePoster
OLIGODENDROCYTE TMEM117 LINKS MYELIN STABILITY TO METABOLIC REGULATION
Melvin Alappatand 9 co-authors
University of Zurich
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-159
Presentation
Date TBA
Board: PS01-07AM-159
Event Information
Poster Board
PS01-07AM-159
Poster
View posterAbstract
Although the effects of metabolic imbalance on myelin content and integrity have been widely studied, the converse relationship—how central nervous system (CNS) myelin homeostasis influences systemic metabolic health—remains poorly understood. Here, we investigate the role of Tmem117, a previously uncharacterized protein, and show that transient disturbances in myelin homeostasis elicit sex-specific alterations in counterregulatory responses, glucose tolerance, and hepatic lipid accumulation in mice. Specifically, loss of Tmem117 in mature oligodendrocytes induces endoplasmic reticulum (ER) stress, disrupts key molecular pathways, and leads to subsequent demyelination. Furthermore, combining evolutionary analyses with in vitro approaches, we provide initial evidence that Tmem117 functions as a stabilizer of the sodium–calcium exchanger NCX1. Collectively, our findings uncover a crucial role for CNS myelin integrity in the regulation of whole-body metabolic homeostasis and identify Tmem117 as a potential cell-specific modulator of NCX1 activity.
Recommended posters
AUTOPHAGY-DEPENDENT MECHANISMS IN OLIGODENDROCYTE MATURATION AND WHITE MATTER INTEGRITY
Isabel Jiménez Ridruejo, Jorge Valero, Guillermo Mariño, Ainhoa Plaza-Zabala
MYELIN-DERIVED FATTY ACIDS AMELIORATE PATHOLOGY IN HUMAN CORTICAL ORGANOIDS FROM ALZHEIMER’S DISEASE
Andrea Sainz Prado, Alberto Pérez-Samartín, Fernando Pérez-Cerdá, Carlos Matute
TETHER-MEDIATED EXTRACTION OF MYELINOID BODIES BY MICROGLIA AND ASTROCYTES CAN MAINTAIN MYELIN INTEGRITY
Sandra Goebbels, Erik Späte, Kieran P. Higgins, Maarten Kole, Lina Komarek, Anna M. Steyer, Wiebke Möbius, Klaus-Armin Nave
CROSSTALK BETWEEN DEVELOPING OLIGODENDROCYTES AND AXONS
Giulia Salzano, Anabela Palandri, Laura Ballerini
CHEMOGENETIC ACTIVATION OF MATURE OLIGODENDROCYTES REVEALS A ROLE FOR MYELIN PLASTICITY IN EMOTIONAL CIRCUITS
Stefano Calovi, Alba Legarda Gonzalez, Ignacio Javier Marin-Blasco, Carla Peiró-Moreno, Pablo Reyes-Velazquez, Maria Villafranca-Faus, Marta Torrent, Federico N. Soria, Raul Andero, Edgar Soria-Gómez, Maria Domercq
THE EFFECT OF OLIGODENDROGLIAL-ADAM10 DEFICIENCY UPON CHEMICAL- OR MECHANICAL-INDUCED CENTRAL NERVOUS SYSTEM DEMYELINATION IN MICE
Pilar Acebo