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TETHER-MEDIATED EXTRACTION OF MYELINOID BODIES BY MICROGLIA AND ASTROCYTES CAN MAINTAIN MYELIN INTEGRITY
Sandra Goebbelsand 7 co-authors
Max Planck Institute for Multidisciplinary Sciences
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-473
Presentation
Date TBA
Board: PS02-07PM-473
Event Information
Poster Board
PS02-07PM-473
Poster
View posterAbstract
Oligodendrocytes make myelin for the electrical insulation of axons and saltatory impulse conduction. Myelin lipids and proteins undergo a slow turnover, but exactly how the multilamellar and compacted membrane sheaths are remodeled without compromising myelin sheath integrity has remained puzzling, in particular at advanced age when myelin abnormalities increase. Earlier EM studies had suggested myelin membranes are shed and subsequently phagocytosed by microglia. However, the formation of multilamellar myelinoid bodies (MBs), leaving a well-ordered myelin sheath behind, is difficult to reconcile with simple shedding mechanisms. Here, we show by three-dimensional FIB-SEM reconstructions of optic nerves in mice and by two-photon live-imaging of myelinated cortical slices that MBs are initially connected to their parental sheaths by long tethers, which are stretched by trogocytosing microglia and astrocytes. We observe ruptured tethers attached to both MBs and sheaths, suggesting a novel mechanism of tension-driven tether scission. Importantly, the successive fusion of the corresponding innermost myelin membranes in an extended tether can preserve myelin sheath integrity. Thus, the remodeling by tether-mediated MB extraction emerges as a mechanism of physiological maintenance of myelin sheaths in the CNS.
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