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SYSTEMIC INFLAMMATION AND REPRODUCTIVE DISORDERS IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Taekyun Shinand 2 co-authors
Jeju National University, College of Veterinary Medicine
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-013
Presentation
Date TBA
Board: PS04-08PM-013
Event Information
Poster Board
PS04-08PM-013
Poster
View posterAbstract
We evaluated whether systemic inflammation occurs during the course of autoimmune disease, focusing on experimental autoimmune encephalomyelitis (EAE). Specifically, we examined the expression and localization of osteopontin (OPN), a pro‑inflammatory mediator, in serum and multiple organs of mice with EAE. In enzyme‑linked immunosorbent assays, serum OPN levels were significantly elevated in EAE mice. In Western blot analyses, OPN expression was upregulated across all tissues examined, including liver, kidneys, intestines, ovaries, and spinal cord. Immunohistochemistry revealed OPN immunoreactivity in inflammatory cells (primarily macrophages) and enhanced expression in constitutively active cell types within these organs. These findings demonstrate that OPN was elevated systemically following EAE induction, supporting the presence of widespread inflammation. Moreover, reproductive organs within the hypothalamus–pituitary–gonadal axis were affected, suggesting that systemic increases in pro‑inflammatory mediators such as OPN may contribute to both reproductive dysfunction and neuronal pathology in the EAE model. (This research was supported by the National Research Foundation of Korea (Grant number: RS-2024-00353429 and NRF-2022R1F1A1074980)
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