Electrogenic Na+/K+-ATPases constrain excitable cell activity and pose additional evolutionary pressure
Liz Weerdmeester, Jan-Hendrik Schleimer and Susanne Schreiber
Bernstein 2024
The evolution of the Na$^+$/K$^+$-ATPase in ancestral methanogenic archaea also lay the foundation for the energetics of energy-intensive signaling tissues like the metazoan nervous systems billions of years later [1]. The electrogenic property of this pump, which leads to activity-dependent feedback [2], seems a…