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ALTERED EEG SPECTRAL POWER AND WORKING MEMORY DEFICITS IN IDIOPATHIC GENERALIZED EPILEPSY
Emre Erdoğanand 4 co-authors
Erciyes University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-260
Presentation
Date TBA
Board: PS01-07AM-260
Event Information
Poster Board
PS01-07AM-260
Poster
View posterAbstract
This study evaluated working memory performance in patients with Idiopathic Generalized Epilepsy (IGE) using the N-back task and investigated the relationship between behavioral performance and EEG spectral power. The study included six IGE patients and an age- and sex-matched healthy control group. Participants performed the N-back task at three cognitive loads (0, 1, and 2-back), where accuracy rates (%) and reaction times (ms) were recorded. EEG recordings underwent spectral analysis to calculate power values for Delta, Theta, Alpha, Beta, and Gamma bands, alongside the Alpha/Theta (ATR) and Alpha/Delta (ADR) ratios.
Results revealed that reaction times were significantly prolonged in the epilepsy group, particularly in the 0-back condition (p = 0.020), indicating impaired basic attentional processing. While accuracy decreased with higher cognitive load in both groups, the decline was more pronounced in the IGE group. EEG analysis showed significantly increased power across all frequency bands in patients; notably, whole-brain theta power was approximately three times higher than in controls. Furthermore, ATR and ADR values were significantly elevated (p < 0.002), suggesting a broadband increase in neural activity. A strong negative correlation trend emerged between right anterior delta activity and 0-back accuracy in patients (rho = −0.829, p = 0.058).
In conclusion, IGE patients exhibit interictal impairments in working memory, attention, and processing speed. These deficits are associated with frontal slow-wave activity and generalized EEG power increases, supporting frontal dysfunction as a potential neurophysiological marker of cognitive impairment in IGE.
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