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ASTROCYTE MODULATE NEUROINFLAMMATION MEDIATED THROUGH ICAM1 IN PROGRESSIVE SUPRANUCLEAR PALSY
Avishek Royand 3 co-authors
Karolinska Institutet
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-140
Presentation
Date TBA
Board: PS01-07AM-140
Event Information
Poster Board
PS01-07AM-140
Poster
View posterAbstract
Progressive supranuclear palsy (PSP) is a primary tauopathy with characteristic synaptic loss, neuroinflammation due to tau-overload. Neuroinflammation is primary to the tau associated insults in these diseases. Previous studies examined cross-tauopathy post-mortem biopsy from cortical/subcortical samples with presence of tufted astrocyte. In fact, studies revealed involvement of kinases in tau-content irrespective of cell types. Quite recently, micro-structural alterations like varicose-projection were reported to be involved in neuroinflammation in secondary tauopathies. However, how astrocytic physiology is altered in PSP is elusive. Here we deployed advance microscopic tools to examine brain- wide astrocytic heterogeneity with special interest on layer specific alteration in frontal and temporal cortex. We found involvement of ICAM1 influencing astrocyte-astrocyte competition for territory encroachment influenced by tau load. Further, ICAM1 possibly play dual role depending on the site of expression between reactive astrocyte and cortical micro vessels. In this work we reported cell-specific astrocytic heterogeneity in PSP depending on tau-load in astrocytes.
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