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BENEFICIAL EFFECTS OF DIET SUPPLEMENTATION WITH <EM>TRANS</EM>-Ε-VINIFERIN IN AN ALZHEIMER’S DISEASE TRANSGENIC MOUSE MODEL
Ambre Touronand 12 co-authors
Université de Poitiers
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-099
Presentation
Date TBA
Board: PS05-09AM-099
Event Information
Poster Board
PS05-09AM-099
Poster
View posterAbstract
Alzheimer’s disease (AD) is a multifactorial disease with both genetic and environmental components. It has been demonstrated that nutritional management, particularly the intake of polyphenols, is important in limiting cognitive decline. The objective of this study was to assess the effects of supplementation with trans-ε-viniferin (TVI), a stilbene eco-sustainably extracted from grapevines, in APPswePS1dE9 transgenic mice (Tg). Three-month-old mice were orally supplemented with 2 mg TVI per pellet daily for 9 months. At the end of the supplementation, behavioral tests were performed including Morris water maze (MWM) and Y-maze. Fecal samples were analyzed by Western blot to quantify amyloid peptide (Aβ) and other AD biomarkers. Finally, [18F]-Fluorodeoxyglucose (18FDG) PET and transcranial ultrasound superresolution microperfusion brain imaging were conducted to evaluate cerebral energetic metabolism and cerebral microcirculation. After supplementation, short-term memory was improved by 50% (% alternation in Y-maze) while long-term memory was unchanged (MWM). The results showed a 53% decrease in the Aβ fecal levels after the first 3 months of treatment. Brain imaging analyses are ongoing, and the first results showed that TVI-supplemented mice exhibited significantly higher 18FDG uptake in subcortical areas. This study shows that a nutritional dose of this phytochemical may be beneficial in this AD Tg model, as it reduces peripheral Aβ burden, increases cerebral metabolic activity and improves short-term memory.
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