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BIOLOGICAL CHARACTERISTICS OF FATIGUE-DOMINANT LONG-COVID PATIENTS: AN OBSERVATIONAL STUDY
Jin-Seok Leeand 1 co-author
Deajeon University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-411
Presentation
Date TBA
Board: PS02-07PM-411
Event Information
Poster Board
PS02-07PM-411
Poster
View posterAbstract
Long-COVID is defined by persistent symptoms following COVID-19 infection. Approximately 71% of individuals with long-COVID experience ongoing fatigue, post-exertional malaise, and cognitive impairments, which share pathological similarities with ME/CFS. To gain insights, we investigated the clinical and laboratory characteristics of 100 subjects with fatigue-dominant long-COVID (36 males, 64 females). We employed fatigue measurements, including the mKCFQ11, MFI-20, and VAS for fatigue and brain-fog, along with the SF-12. We also measured three cytokines and cortisol levels for immunological and endocrinological indicators. The mean scores on the measurements showed severe fatigue, and these scores were significantly correlated, with no differences based on sex, the post-COVID period, or age. Among the laboratory tests, plasma cortisol levels had a significant negative correlation with fatigue scores and a positive correlation with living quality. Our findings provide the first insights into the characteristics of fatigue in individuals with long-COVID, particularly in terms of fatigue severity and cortisol levels.
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