Poster preview
ePoster
CROSS-SPECIES IN VIVO IMAGING REVEALS AUTOPHAGY DYNAMICS DURING SLEEP AND WAKEFULNESS
Paulina Schnurand 2 co-authors
University of Oslo
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-214
Presentation
Date TBA
Board: PS05-09AM-214
Event Information
Poster Board
PS05-09AM-214
Poster
View posterAbstract
Autophagy is a highly dynamic process influenced by systemic physiological states, yet technical limitations have constrained investigation of its role across the sleep–wake cycle. In this project, we investigate autophagy as a potential mediator of sleep benefits, mapping its temporal dynamics across the sleep–wake cycle in both Drosophila and mice. We are developing a real-time in vivo imaging approach to quantify autophagy in the brain, enabling spatially and temporally resolved measurements under baseline conditions and during sleep deprivation.
The newly developed method for real-time in vivo monitoring of autophagy will further allow us to elucidate the whole-organism orchestration of autophagy regulation and termination. This approach will enable us to connect cellular autophagy dynamics to behavioural states, integrating molecular, tissue-level, and organism-level perspectives on sleep functions.
The newly developed method for real-time in vivo monitoring of autophagy will further allow us to elucidate the whole-organism orchestration of autophagy regulation and termination. This approach will enable us to connect cellular autophagy dynamics to behavioural states, integrating molecular, tissue-level, and organism-level perspectives on sleep functions.
Recommended posters
LONGITUDINAL AUTOPHAGY PROFILING OF THE MAMMALIAN BRAIN REVEALS SUSTAINED MITOPHAGY THROUGHOUT HEALTHY AGING
Anna Rappe, Iné Alvarez van Tussenbroek, Helena A. Vihinen, Fumi Suomi, Homa Ehsan, Antti J. Hassinen, Eija S. Jokitalo, Graham M. Hughes, Sonja C. Vernes, Thomas G. McWilliams
UNCONSTRAINED SLEEP RESEARCH: USING MINI2P IMAGING AND ELECTROPHYSIOLOGY TO INVESTIGATE NATURAL SLEEP DYNAMICS IN MICE
Fabian Heimel, Alessio Nespoli, Luca Bordoni, Rune Enger
SLEEP-DEPENDENT MICROGLIAL CALCIUM DYNAMICS IN ALZHEIMER’S DISEASE MOUSE MODELS
Nicole Byron, Niall McAlinden, Alba Pascual Clavel, Marco Pisanello, Keith Mathieson, Massimo De Vittorio, Ferruccio Pisanello, Shuzo Sakata
TARGETED CHEMOGENETIC MODELS OF EARLY-ADOLESCENT SLEEP DISTURBANCE – METABOLIC CONSEQUENCES IN MICE
Sandra Kristine Stølen Bryne, Damien Dufour, Nolwenn Briand, Charlotte Nina Boccara
THE ORCHESTRA OF SLEEP: DRD1-EXPRESSING NEURONS IN THE CENTRAL CLOCK AS THE CONDUCTOR OF SLEEP AND AUTONOMIC BALANCE IN RATS
Vanessa Veronica, Valentina Rumanova, Susanne la Fleur, Andries Kalsbeek
STUDYING NEURONAL AUTOPHAGY IN HUMAN AGEING USING INDUCED NEURONS DIRECTLY REPROGRAMMED FROM ADULT HUMAN DERMAL FIBROBLASTS
Roland Zsoldos, Kinga Vörös, Zsófia Koltai, Chandramouli Muralidharan, Anikó Göblös, Idris János Jimoh, Bence Király, Anna Anoir Abbas, Balázs Kis, Ágnes Varga, Csaba Kerepesi, Johan Jakobsson, Mária Judit Molnár, Lajos Kemény, Karolina Pircs