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DISTINCT POPULATION DYNAMICS IN SUBREGIONS OF THE MEDIAL PREFRONTAL CORTEX DURING ACTION PROMOTION AND INHIBITION
Felice Veenand 4 co-authors
Netherlands Institute for Neuroscience
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-227
Presentation
Date TBA
Board: PS03-08AM-227
Event Information
Poster Board
PS03-08AM-227
Poster
View posterAbstract
The inability to inhibit unwanted behavior is a recurrent trait in psychiatric conditions such as obsessive-compulsive disorder and addictions, suggesting dysfunctional promotion and inhibition of appetitive actions. While the prelimbic (PL) and infralimbic (IL) cortices are known to support complementary roles in action regulation, how they encode behavioral promotion and inhibition at the population level remains unclear. To address this, we used calcium imaging to record PL and IL activity in rats performing a go/no-go task that incorporated a rule switch to a Differential Reinforcement of Omission (DRO) contingency. We found that although PL and IL recruited similar numbers of behaviorally responsive neurons, dimensionality-reduction analyses revealed distinct population dynamics in each region, specifically during DRO. These findings suggest that PL and IL support distinct encoding strategies for behavioral control following contingency changes, despite similar single-unit recruitment.
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