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EFFECTS OF STRIATAL TRANSCRANIAL TEMPORAL INTERFERENCE STIMULATION ON HAND MOTOR CONTROL IN STROKE SURVIVORS
Camille E. Proulxand 6 co-authors
Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-102
Presentation
Date TBA
Board: PS07-10AM-102
Event Information
Poster Board
PS07-10AM-102
Poster
View posterAbstract
Post-stroke sensorimotor deficits significantly impair hand function and participation in daily life, yet neurorehabilitation does not consistently lead to satisfactory recovery. While non-invasive brain stimulation (NIBS) can improve motor function, it fails to target deep brain structures like the striatum, key for motor control, including precision feedback and grip force scaling. Transcranial temporal interference stimulation (tTIS) is a novel, transformative NIBS method that allows to target subcortical areas (Wessel et al. 2023), though its effects in stroke populations remain unexplored. This ongoing study examines the effects of striatal tTIS on hand motor control in stroke survivors with upper-limb deficits (current N = 24/30), hypothesizing improved motor performance compared to a control condition. Participants perform a visuomotor grip force task following a quadruple-blinded crossover paradigm: once with concomitant theta-burst patterned tTIS targeting the striatum (carrier frequencies f1 = 2.00 kHz, f2 = 2.10 kHz), and once with a high-frequency control condition (f1 = f2 = 2.00 kHz). The primary outcome is grip force accuracy, with overshooting and undershooting as secondary outcomes. The data remain blinded regarding verum vs placebo tTIS. Preliminary analyses in 24 participants indicate a significant difference (p<0.0001, 𝜂² = 0.07) in grip force accuracy between stimulation conditions, with no significant differences observed for overshooting (p = 0.66) and undershooting (p = 0.27). This provides first evidence for the feasibility of applying tTIS in stroke populations and highlights its potential to modulate hand motor control by targeting deep motor-related brain structures, opening new avenues for individualized stroke rehabilitation.
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