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ELECTROPHORETIC PRECISION DELIVERY DECOUPLES DOSE FROM VOLUME FOR IN SITU PHARMACOLOGY
Theresia Arbring Sjöström
Linköping University
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-610
Presentation
Date TBA
Board: PS02-07PM-610
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Poster Board
PS02-07PM-610
Poster
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Biological barriers such as dense extracellular matrices, poor vascularization, and rapid clearance make large tissue regions difficult to reach with systemic drug delivery. This limitation is particularly acute in the central nervous system, where the blood brain barrier restricts access and pressure driven infusion can perturb delicate tissue. Methods that can shape local exposure with high spatial and temporal control, without adding fluid volume, would reduce common mechanical and transport confounds.
We develop implantable electrophoretic drug delivery devices that use polyelectrolyte hydrogels for selective transport of charged biomolecules or drug compounds. In contrast to pressure driven approaches, electrophoretic transport enables programmable local release without bulk solvent flow, thereby decoupling delivered dose from infused volume. Dose control is quantitative in principle because delivery can be related to passed charge and calibrated by transport efficiency. After release, molecules spread from the outlet primarily by diffusion and clearance, making the approach naturally compatible with diffusion-based modeling to design dosing protocols that shape or maintain local concentration gradients over time. Together, this establishes electrophoretic implants as a general, flow-free strategy for in situ pharmacology in tissue environments that are difficult to access with systemic dosing.
We develop implantable electrophoretic drug delivery devices that use polyelectrolyte hydrogels for selective transport of charged biomolecules or drug compounds. In contrast to pressure driven approaches, electrophoretic transport enables programmable local release without bulk solvent flow, thereby decoupling delivered dose from infused volume. Dose control is quantitative in principle because delivery can be related to passed charge and calibrated by transport efficiency. After release, molecules spread from the outlet primarily by diffusion and clearance, making the approach naturally compatible with diffusion-based modeling to design dosing protocols that shape or maintain local concentration gradients over time. Together, this establishes electrophoretic implants as a general, flow-free strategy for in situ pharmacology in tissue environments that are difficult to access with systemic dosing.
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