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ePoster
ENHANCEMENT OF SYNAPTIC AMPA RECEPTORS DEPENDS MUTUALLY ON SRC AND PSD-95
Xiaojie Huangand 8 co-authors
University of Pittsburgh
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS03-08AM-515
Presentation
Date TBA
Board: PS03-08AM-515
Event Information
Poster Board
PS03-08AM-515
Poster
View posterAbstract
Synaptic incorporation and removal of AMPA receptors is highly regulated to modulate the strength of synaptic transmission for long-term synaptic plasticity during brain development and associative learning. PSD-93α2 and PSD-95α, two paralogs of the DLG-MAGUK protein family of signaling scaffolds govern the synaptic incorporation and stabilization of AMPA receptors opposingly, with PSD- 95α promoting and PSD-93α2 inhibiting it. We identified the protein motifs responsible for the opposing roles of PSD-93α2 and PSD-95α in enhancing AMPA receptors at synapses. We demonstrated that synaptic incorporation of AMPARs depends on Src activation at PSD95α, potentially via N-terminal domain of PSD95α. Together, the results depict a mutual dependence of Src and PSD-95α in enhancing and maintaining synaptic AMPA receptors.
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