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GENETIC DISRUPTION OF A LRRTM4 ORTHOLOGUE IN ZEBRAFISH REDUCES AGGRESSION AND PROMOTES SOCIAL BEHAVIOUR
Eva Tatzland 14 co-authors
Medical University of Graz
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS07-10AM-368
Presentation
Date TBA
Board: PS07-10AM-368
Event Information
Poster Board
PS07-10AM-368
Poster
View posterAbstract
Leucine rich repeat transmembrane proteins (LRRMT1-4) are synaptic adhesion proteins able to influence synapse development and function. Polymorphisms of the LRRTM4 gene have been linked to multiple neuropsychiatric diseases and aggression, but the underlying mechanisms are currently unclear. Therefore, we aimed to better understand the role of this gene for behaviour by using zebrafish as a model system. In two different lrrtm4l1-/- zebrafish lines (KO) we found that KO animals are less aggressive and display altered anxiety. In addition, the KO line with a loss of function mutation earlier in the gene showed a pro-social phenotype. RNAseq analysis of brain tissues revealed numerous differentially expressed genes between KO and WT samples and the brain metabolome was significantly different as well. Among altered biological pathways, changes in the dopaminergic and serotonergic system are of particular interest. In conclusion, our data suggest that lrrtm4l1 plays an important role for zebrafish behaviour and strongly regulates the brain transcriptome and metabolome. These findings may help to better understand the link between human LRRTM4 polymorphisms and neuropsychiatric disease.
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