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HYPOTHALAMIC ASTROCYTES ARE NECESSARY TO CONTROL BODY WEIGHT AND LIPID ACCUMULATION THROUGH INSULIN SIGNALING
Raquel Gil Vargasand 6 co-authors
CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-671
Presentation
Date TBA
Board: PS01-07AM-671
Event Information
Poster Board
PS01-07AM-671
Poster
View posterAbstract
The hypothalamus is the main region responsible for controlling metabolic homeostasis and generates responses to peripheral signals such as hormones, including insulin. This hormone is involved in glucose metabolism. It exerts its function through binding to its receptor (IR), but it also acts by binding to the Insulin-like Growth Factor 1 (IGF-1) receptor (IGF1R) and to hybrid receptors composed of both types, thereby allowing activation of the same signaling pathways. At the central level, insulin regulates glucose transport into the brain and is essential for the regulation of glucose homeostasis. In addition to neurons, glial cells also express both receptors. However, the insulin signaling in astrocytes in obesity context induced by high fat diet was not explored.
This study investigates the IR and the IGF1R from hypothalamic astrocytes in the regulation of metabolism. The work was performed using a murine model, the IR and IGF1R inducible double knock out in Glast-expressing astrocytes of male mice. These animals were exposed to chow, 5 or 15 days of high fat diet.
Through molecular and histological techniques, our results show that the action of both receptors is necessary to increase the body weight in response to high fat diet and the deletion of both receptors produces a tendency to increase the lipid accumulation.
This study investigates the IR and the IGF1R from hypothalamic astrocytes in the regulation of metabolism. The work was performed using a murine model, the IR and IGF1R inducible double knock out in Glast-expressing astrocytes of male mice. These animals were exposed to chow, 5 or 15 days of high fat diet.
Through molecular and histological techniques, our results show that the action of both receptors is necessary to increase the body weight in response to high fat diet and the deletion of both receptors produces a tendency to increase the lipid accumulation.
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