Back to FENS Forum 2026
ePoster

LOSS OF FUNCTION OF NOGGIN INHIBITS GLIAL SCAR FORMATION AND MOTOR FUNCTION RECOVERY AFTER SPINAL CORD INJURY

Satoru Yamagishiand 8 co-authors

Hamamatsu University School of Medicine

FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-100

Presentation

Date TBA

View poster
Board: PS04-08PM-100

Poster preview

LOSS OF FUNCTION OF NOGGIN INHIBITS GLIAL SCAR FORMATION AND MOTOR FUNCTION RECOVERY AFTER SPINAL CORD INJURY poster preview

Event Information

Poster Board

PS04-08PM-100

Abstract

Noggin is a glycosylated protein that can act as an inhibitor of bone morphogenetic proteins, promoting astrogliosis and functional recovery after spinal cord injury (SCI). Although Noggin has been shown to inhibit astrocytic proliferation, it does not seem to affect glial scar size, and thus its underlying mechanisms remain to be elucidated. Under normal conditions, Noggin is expressed in fibroblasts in the sges and astrocytes in the white matter. Here, we show that Noggin is upregulated in reactive astrocytes after SCI, indicating its involvement in the injury response. Surprisingly, Noggin elimination from astrocytes and neurons in the spinal cord using Nestin-Cre; Nogginlx/lx conditional knockout mice strongly suppresses glial fibrillary acidic protein (GFAP) expression after SCI. Consistent with this result, administration of neutralizing anti-Noggin antibodies to the lesion site using micro osmotic pumps inhibited GFAP expression, and it deteriorated motor behavior after SCI. These findings suggest that Noggin is a key regulator of astrogliosis and plays an important role in glial scar formation, and decreased glial scar formation may not improve motor function after SCI.

Recommended posters

COACERVATES DELIVER PROLIFERATION CUES TO ASTROCYTES FOR IMPROVED WOUND HEALING AFTER INJURY

Laboni Hassan, Honour Adewumi, Kunyu Li, Timothy O'Shea

TARGETING LSD1 TO REDUCE NEUROINFLAMMATION AND PROMOTE FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY

Ayesha Niaz, Clara Penas Perez

A NANOGEL-BASED DRUG DELIVERY SYSTEM FOR OLIGODENDROCYTE PRESERVATION IN SPINAL CORD INJURY

Emilia Petillo, Giuseppe Nunziata, Valeria Veneruso, Enrico Frigerio, Lucia Burnacci, Francesca Ghirardi, Lisa Del Rio, Filippo Rossi, Pietro Veglianese

AN IN VITRO GLIAL SCAR MODEL TO ASSESS SURVIVAL AND INTERACTIONS OF SCHWANN-LIKE CELLS WITH NEURITES FOR NEURAL REGENERATION

Gabriela Reyes-Gutierrez, Nidia Jannette Carrillo-González, Gabriela Escobar-Camberos, Graciela Gudiño-Cabrera

ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS OF INFLAMMASOME INHIBITORS FOLLOWING CONTUSION SPINAL CORD INJURY

Barnabás Pájer, Krisztián Pajer, Rebeka Kristóf, Tamás Bellák, Ádám Mészáros, Dénes Török, Zoltán Fekécs, Antal Nógrádi

CAMP-INDUCED TRANSCRIPTIONAL PROFILING PROVIDES INSIGHTS INTO THE BIOLOGY OF SPINAL CORD INJURY HEALING

Ana Isabel Fraga Sanchez, Loris Mannino, Samuel Martín-Pérez, Eric López-Mocholi, Quique Vidal Beneyto, Ana Conesa, Esther Giraldo, Guillem Paniagua Soriano, Victoria Moreno-Manzano

Cookies

We use essential cookies to run the site. Analytics cookies are optional and help us improve World Wide. Learn more.