ePoster

POWER-SPECTRAL CHARACTERISTIC OF MICROSTATES IN MULTIPLE SCLEROSIS

Marek Tobiášand 2 co-authors

Charles University

FENS Forum 2026 (2026)

Barcelona, Spain

Board PS03-08AM-025

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Board: PS03-08AM-025

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PS03-08AM-025

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Abstract

Microstates in resting-state brain activity recorded by electro-encephalography (EEG) are global, quasi-stable patterns of activity that recur in time and characterize brain state dynamics. In patients with multiple sclerosis (MS), Baldini et al (2023) reported alterations of microstate statistics that they associated with the disease. In this study we first aim at replicating the findings of Baldini et al on EEG from 26 MS patients and 27 age-matched healthy controls but find conflicting results - the occurrence of microstates was not significantly different between MS and control subjects, and we did not observe any association of microstate parameters with clinical markers, potentially due to a lower number of patients in our study. An alternative reason may be that the changes observed by Baldini et al. were related to non-specific symptoms that can also occur in control subjects such as fatigue. Based on analysis of power spectra associated with each microstate, we find that microstates are indeed accompanied with distinct power-spectral properties and vigilance levels that match the microstate interpretation based on fMRI studies.
[Baldini 2023] Sara Baldini, Maria Elisa Morelli, Arianna Sartori, Fulvio Pasquin, Alessandro Dinoto, Alessio Bratina, Antonio Bosco and Paolo Manganotti, Microstates in multiple sclerosis: an electrophysiological signature of altered large-scale networks functioning?, Brian Communications 2023, https://doi.org/10.1093/braincomms/fcac255

POWER-SPECTRAL CHARACTERISTIC OF MICROSTATES IN MULTIPLE SCLEROSIS

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